Hepatitis E Infection in Humans and in Environment
Conditions
Brief summary
The present research aims to collect virological and clinical data on hepatitis E virus (HEV) infections, either in acute or chronic forms of HEV infection in North-Eastern France, with liver- or non liver-related symptoms, plus data on HEV circulation in the outside environment. The purpose of this study is to improve the diagnosis and care of HEV-infected patients, as well as the preventive features to take into account in order to avoid food- and environment-borne infections. At last, we will investigate HEV molecular characteristics, with the hypothesis that some advantageous HEV strains coul be more pathogenic for some tissues and/or organs.
Interventions
OTHEROnly advice for diagnosis and prevention
Only advice for diagnosis and prevention
Sponsors
Central Hospital, Nancy, France
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* HEV-infected patients, with hepatitis and/or neurological and/or renal symptoms
Exclusion criteria
* Patients, with hepatitis and/or neurological and/or renal symptoms, infected by other viruses leading to hepatitis (hepatitis B, hepatitis C, hepatitis A ...)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Anti-HEV IgM (qualitative assay); | 2 years | Guidelines to improve HEV detection by using the 2 virological assays |
| HEV RNA (quantitative PCR assay) | 2 years | Guidelines to improve HEV detection by using the 2 virological assays |
Countries
France
Contacts
Primary ContactEvelyne SCHVOERER, Pr
Outcome results
None listed