Changes in the Gut Microbiota During an Antibiotic Treatment
Conditions
Keywords
antibiotics, prebiotics, dysbiosis
Brief summary
Antibiotics disturb the balance of gut microbiota causing dysbiosis. The purpose of this double-blind placebo controlled intervention study is to investigate whether a new prebiotic product could prevent the side effects of antibiotics.
Detailed description
Thirty children (2-6 years of age), who require antibiotic treatment assessed by a doctor, will be enrolled in the study. The children will be randomized to receive either the prebiotic product or placebo during the course of antibiotic treatment. The children will give a faecal sample in the beginning and at the end of the study. The samples will be used for the analysis of microbiota and differences in the microbiota between the groups.
Interventions
DIETARY_SUPPLEMENTPrebiotic product
Prebiotic product used during the course of antibiotic treatment
DIETARY_SUPPLEMENTPlacebo
Placebo
Sponsors
VTT Technical Research Centre of Finland
Turku University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
SINGLE (Investigator)
Intervention model description
Double blind placebo controlled trial
Eligibility
Sex/Gender
ALL
Age
2 Years to 6 Years
Healthy volunteers
No
Inclusion criteria
* An infection requiring antibiotic treatment assessed by a doctor
Exclusion criteria
* Coaeliac disease or allergy to cereals, use of other prebiotic/probiotic product during the study
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Changes of gut microbiota during antibiotic treatment | One week | Gut microbiota and antibiotics - Prevention of side effects by new prebiotics |
Contacts
Primary ContactSeppo salminen, PhD
Backup ContactErika Isolaur, MD,PhD
Outcome results
None listed