Effect of Food on Postprandial Hyperglycemia
Conditions
Brief summary
Orange juice naturally contains high concentrations of hesperidin, which affects glucose absorption in in vitro experiments. This study is to test if hesperidin and other components of orange juice (not other sugars or organic acids) affect the post-prandial blood glucose concentration derived from sugars already present in the orange juice.
Detailed description
Healthy volunteers will consume orange juice with added water or food-grade hesperidin.
Interventions
OTHERcontrol
balancing sugars and organic acids
OTHERtest meal 1
orange juice plus hesperidin low dose
OTHERtest meal 2
orange juice plus hesperidin higher dose
OTHERtest meal 3
diluted orange juice plus hesperidin low dose
Sponsors
University of Leeds
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* fasting blood glucose below 5.9 mM
Exclusion criteria
* fasting glucose above 6 mM pregnant
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Blood glucose concentration | 3 hours | iAUC/\[glucose\]max |
Countries
United Kingdom
Outcome results
None listed