Left Ventricular Diastolic Function During Anesthesia Induction

Influence of Left Ventricular Diastolic Function on Hemodynamic Stability During Anesthesia Induction and on Postoperative Complications

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03522194

Enrollment

200

Registered

2018-05-11

Start date

2017-04-01

Completion date

2018-09-27

Last updated

2019-03-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Left Ventricular Diastolic Dysfunction

Brief summary

Diastolic dysfunction is an important cause of hemodynamic instability in the perioperative field.Therefore this study aims to investigate the influence of existing diastolic dysfunction or deterioration of diastolic function on hemodynamic stability during induction of anesthesia and postoperative complications. The impact of different anesthetics on diastolic function is investigated.

Detailed description

In this prospective observational study two cohorts of patients with different anesthesia regimes are investigated. Anesthesia is maintained with sevoflurane or propofol. Before induction of anesthesia a transthoracic echocardiography is performed to examine systolic and diastolic function. Immediately after induction, during maintenance and after completion of anesthesia any changes of diastolic function are examined with transthoracic echocardiography. All anesthetic medications, fluids, vasoactive medications and catecholamines are registered.

Interventions

DRUGSevoflurane

Anesthesia maintenance with Sevoflurane

DRUGPropofol

Anesthesia maintenance with Propofol

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

60 Years to No maximum

Healthy volunteers

Inclusion criteria

* Patients older than 60 years scheduled for general anesthesia

Exclusion criteria

* Mitral regurgitation or stenosis \> I° * Sp. mitral valve repair or replacement * Pericardial effusion * Atrial fibrillation/flutter * Patients with pacemaker * BMI \> 35 kg/m2

Design outcomes

Primary

Measure	Time frame	Description
Norepinephrine	30 minutes after induction of anesthesia	Cumulative dose of norepinephrine (adjusted for body weight) during the first 30 minutes after induction of anesthesia

Secondary

Measure	Time frame	Description
e'	Directly after induction of anesthesia	Change of the echocardiographic tissue doppler parameter e' after induction of anesthesia
E / e'	Directly after induction of anesthesia	Change of the echocardiographic index of transmitral flow and tissue doppler after induction of anesthesia

Countries

Germany

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026