Progesterone Resistance
Conditions
Brief summary
to examine if a natural daytime variation in progesterone levels may explain parts of the inconsistent findings from studies reporting divergent results concerning this matter and will be carried out by several blood samples from the same patient during the day of ovulation triggering.
Detailed description
The impact of the progesterone level at the end of the follicular phase in stimulated IVF/ICSI cycles and its effect on the pregnancy rate and oocyte quality is controversial, which arises from conflicting results in retrospective studies and meta-analyses. This study is assumed to examine if a natural daytime variation in progesterone levels may explain parts of the inconsistent findings from studies reporting divergent results concerning this matter and will be carried out by several blood samples from the same patient during the day of ovulation triggering. If variation is present, the impact of variation on the developing oocyte and embryo quality will be estimated by embryo quality indicators.
Interventions
DIAGNOSTIC_TESTProgesterone variation
The potential gain for medical caretakers and patients would be a certainty if the progesterone level is affected by variations during daytime
Sponsors
ART Fertility Clinics LLC
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
* patients 18-45 years * BMI 18-35 kg/m2 * Menstrual cycle length 24-35 days * Stimulation with rFSH or hMG
Exclusion criteria
* None
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The variation of serum progesterone around the ovulation triggering in IVF-cycles | 6-8 months | the circadian secretion-pattern of progesterone during early follicular phase of normal cycling females |
Countries
United Arab Emirates
Outcome results
None listed