Type2 Diabetes
Conditions
Keywords
sex hormone-binding globulin
Brief summary
Sex hormone-binding globulin(SHBG) is a surrogate marker of insulin resistance. This study aims at the characteristic and clinical significance of SHBG and testosterone in patients with type 2 diabetes(T2D).
Detailed description
The investigators recorded clinical factors, biochemical criterion such as serum levels of glucose and lipids, HbA1c, SHBG, testosterone, insulin, EPO, C-peptide, glucagon, microalbuminuria, glycemic variation via CGM, carotid plaque, ECG and ultrasonic cardiogram in patients with T2D who visited in the Department of Endocrinology at the Nanjing First Hospital from January 2015 to Aprol 2018. The relationship between levels of SHBG, testosterone and glycemic variation/diabetic complications are analysed.
Interventions
None listed
Sponsors
Nanjing First Hospital, Nanjing Medical University
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
MALE
Healthy volunteers
No
Inclusion criteria
● Patients with T2D and the diagnostic criteria of T2D is according to the World Health Organization in 1999.
Exclusion criteria
* Patients use systemic steroidal anti-inflammatory drugs. * Patients with an acute infection. * Patients with acute complication of diabetes.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| sex hormone-binding globulin | Day 1 | the blood sex hormone-binding globulin level of patients |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| EPO | Day 1 | blood erythropoietin level of patients |
| HbA1c | Day 1 | the glycosylated hemoglobin level of patients |
| Testosterone | Day 1 | blood testosterone level of patients |
| MAGE | Day 1-4 | the 24h mean amplitude of glycemic excursion |
| SD | Day 1-4 | the standard deviation of mean glucose |
| MBG | Day 1-4 | 24h mean blood glucose tested by CGM |
Outcome results
None listed