Primary Ovarian Insufficiency
Conditions
Brief summary
Premature ovarian insufficiency (POI) is a clinical syndrome defined by loss of ovarian activity before the age of 40 years. The POI guideline development group of ESHRE recommends the following diagnostic criteria: oligo/ amenorrhea for at least 4 months and an elevated follicle stimulating hormone (FSH) level \>25 mIU/mL on two occasion \>4 weeks apart. Some clinicians and researchers proposed that POI was a progressive disease and there were three stages of POI: occult POI, biochemical POI, overt POI. However, there is lack of reliable indicators to assess the different stages of POI. The present study is to explore the change of menstruation condition, basal follicle-stimulating hormone, anti-müllerian hormone and antral follicle count during the development of POI, and whether those marks can assess the different stages of POI.
Interventions
None listed
Sponsors
Nanfang Hospital, Southern Medical University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
12 Years to 40 Years
Healthy volunteers
No
Inclusion criteria
* Serum FSH levels ≥10mIU/ml/ serum AMH levels ≤1.0pg/ml/ AFC ≤5, on at least two occasion \>4 weeks apart
Exclusion criteria
* Polycystic Ovarian Syndrome * other causes of amenorrhea
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| the change of serum follicle-stimulating hormone levels | Every 3 months from date of recruit until the date of study completion, assessed up to 48 months | the serum FSH levels between day 2 to day 5 of menstrual cycle |
| the change of menstruation situation | Every 3 months from date of recruit until the date of study completion, assessed up to 48 months | Menstrual cycle |
| the change of serum anti-mullerian hormone levels | Every 3 months from date of recruit until the date of study completion, assessed up to 48 months | the serum anti-mullerian hormone levels between day 2 to day 5 of menstrual cycle |
| the change of antral follicle count | Every 3 months from date of recruit until the date of study completion, assessed up to 48 months | Antral follicle count between day 2 to day 5 of menstrual cycle |
Countries
China
Contacts
Primary ContactShiling Chen, M.D./Ph.D.
Outcome results
None listed