Parkinson Disease
Conditions
Keywords
Levodopa, axial symptoms
Brief summary
Pilot study: * Longitudinal follow up of the PRODY-GI cohort for parkinson's disease (PD) * Observational study of upper and lower axial symptoms' occurence in 30 PD patients in on and off drug conditions, 30 aged matched control subjects and 10 control subjects with supra nuclear palsy * Multi modal approach: functional MRI, clinical , ENT assessment, respiratory assessment, neuropsychological and gait evaluations
Detailed description
Prospective, clinical assessment of : * Cognition and diadochokinetic task during fMRI in 30 PD patients (in off and on condition) * Motor assessment using VICON gait and balance analysis * Pulmonary functional testing in OFF and ON drug condition * Quality of life * Clinical neurological MDS UPDRS , N Fog questionnaire * ENT and speech therapist evaluation in OFF and ON drug condition
Interventions
None listed
Sponsors
France Parkinson Association
University Hospital, Lille
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 85 Years
Healthy volunteers
Yes
Inclusion criteria
Parkinson's Disease group : Patients with Parkinson's Disease, who where included in the PRODYGI-1 cohort still meeting the MP criteria, Always followed in the service of neurology and pathology of the movement. Pathological control group: * Patients suffering from Richardson syndrome. * Aged over 18 Healthy control group: * Age-matched (± 5 years) * Recruited on the basis of volunteering. * free from any progressive neurological pathology after clinical examination and MoCA.
Exclusion criteria
For all groups: * Pregnant or lactating woman * Extra-neurological severe respiratory pathology * Terminal heart failure * Contraindication to MRI * Refusal / withdrawal / inability to give consent * ENT pathology.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in the neural network between patients in OFF levodopa conditions and control subjects | Between two evaluation visits, on average at 3 months (baseline- 3 months) | Measure evaluated by functional MRI during the realisation of a cognitive task: symbol digit modality test |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in the neural network between patients in OFF-drug conditions and healthy control subjects | Between two evaluation visits, on average at 3 months (baseline- 3 months) | Measure evaluated by functional MRI during the realisation of two motor tasks |
| Change in the neural network between OFF-drug condition and ON-drug condition in patients | Between two evaluation visits, on average at 3 months (baseline- 3 months) | Measure evaluated by functional MRI, during the realisation of one cognitive task and two motor tasks |
| Change in the neural network between patients in OFF-drug conditions and neurological control subjects (with supra nuclear palsy) | Between two evaluation visits, on average at 3 months (baseline- 3 months) | Measure evaluated by functional MRI, during the realisation of one cognitive task and two motor tasks |
Countries
France
Outcome results
None listed