Pregnancy
Conditions
Keywords
gingivitis, saliva, gingival crevicular fluid
Brief summary
The aim of this study was to investigate salivary and gingival crevicular fluid (GCF) levels of MMP-8, MMP-9 and TIMP-1 during 2/3 trimester of pregnancy and after delivery
Detailed description
MMP-8 and MMP-9 have been reported to reflect the inflammatory status in periodontal tissues and, therefore represent as potential biomarkers of periodontitis. The balance between tissue inhibitors of metalloproteinases (TIMPs) and MMPs play an important role in maintaining the integrity of healthy periodontium.
Interventions
OTHERSaliva collection
OTHERGCF collection
Sponsors
Aydin Adnan Menderes University
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
* Pregnant group included women, who were in their second trimester (weeks 16-24) and third trimester (weeks 25-34)
Exclusion criteria
* (a) any known systemic disease, (b) periodontal treatment within the last six months, (c) patients having less than 10 teeth, (d) smokers and (e) individuals with BMI \> 30 kg/m2
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Changing MMP-8 levels | 6 months | Salivary and GCF level measured by IFMA |
| Changing MMP-9 levels | 6 months | Salivary and GCF level measured by ELISA |
| Changing TIMP-1 levels | 6 months | Salivary and GCF level measured by ELISA |
Outcome results
None listed