Combined Dental Bleaching Protocols and Time Required to Achieve Satisfactory Color

Effect of a Single Prior Session of In-office Dental Bleaching on Time Required to Obtain Satisfactory Tooth Color With At-home Bleaching

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03514797

Enrollment

Registered

2018-05-02

Start date

2018-04-13

Completion date

2018-06-30

Last updated

2019-04-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Tooth Discoloration

Keywords

Tooth bleaching, Hydrogen peroxide, Carbamide peroxide, Tooth Bleaching Agents

Brief summary

This parallel, randomized, and controlled clinical trial will assess the effect of a single prior session of in-office dental bleaching on time required to achieve satisfactory tooth color with at-home bleaching. Participants enrolled will randomly allocated to receive or not a single session of dental bleaching with 35% hydrogen peroxide applied for 45 min. Following, all participants will use customized trays filled with 10% carbamide peroxide for 1h per day until obtain satisfactory results. The primary outcome will be the number of days necessary to obtain satisfactory tooth color. Furthermore, tooth sensitivity and color changes measured with spectrophotometer will be assessed.

Interventions

DRUGBleaching Agents

In-office tooth bleaching with 35% hydrogen peroxide in a single application of 45 minutes.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 40 Years

Healthy volunteers

Yes

Inclusion criteria

* Good general and oral health; * Upper canines darker than the tab 2.5M2 at VITA Bleachedguide 3D-MASTER® (Vita-Zahnfabrik, Bad Sackingen, Germany) scale.

Exclusion criteria

* Presence of non-treated caries or periodontal disease; * Prior tooth hypersensitivity; * Presence of gingival recession; * Teeth with cracked enamel or any hypoplasia; * Patients using oral removable or fixed orthodontic appliances; * Patients were pregnant or breastfeeding.

Design outcomes

Primary

Measure	Time frame	Description
Time to tooth color satisfaction	up to 1 month after beginning the tooth bleaching procedures	Time in days performing at-home bleaching necessary to participant reports that is satisfied with the tooth color obtained

Secondary

Measure	Time frame	Description
Color change	up to 1 month after beginning the tooth bleaching procedures	Values of delta E measured with a spectrophotometer from color at baseline
Tooth sensitivity	1, 2, 3, and 4 week after beginning the tooth bleaching procedures	Maximum level of tooth sensitivity reported by participants using an analogue visual scale. The distance between the patient's marking and the no pain border was recorded in cm.

Countries

Brazil

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026