Infertility
Conditions
Keywords
in vitro fertilization, intracytoplasmic sperm injection, fertilization, Assisted reproduction
Brief summary
In this prospective randomized clinical trial we plan to compare two fertilization method which are widely used during in vitro fertilization (IVF) treatment. Outcome of conventional IVF and intracytoplasmic sperm injection (ICSI) treatment will be compared in this study.
Interventions
PROCEDUREICSI
Oocytes are fertilized by conventional in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI)
Sponsors
Semmelweis University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Caregiver, Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 48 Years
Healthy volunteers
No
Inclusion criteria
Infertile patients entering in vitro fertilization treatment At least 1 oocytes collected Semen sample is suitable for IVF and ICSI fertilization as well Number of oocytes collected is lower than 5 AND/OR female age is equal or more than 40 years
Exclusion criteria
Samen sample is not suitable for conventional IVF fertilization Previous conventional IVF treatment resulted in \<50% fertilization rate
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Fertilization rate | 18 hours after insemination | Number of oocytes fertilized |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Embryo quality | 36 and 72 hours after fertilization | Number and quality of blastomeres, amount of fragmentation, embryo grade |
| Implantation rate | 4 weeks after embryo transfer | Number of embryos implanted (/number of embryos transferred) |
| Clinical pregnancy rate | 4 weeks after the embryo transfer | Number of clinical pregnancies (/No. of embryo transfers) |
Countries
Hungary
Contacts
Primary ContactPeter Fancsovits, PhD
Backup ContactJanos Urbancsek, DSc
Outcome results
None listed