Meconium Obstruction of Prematurity, Respiratory Distress Syndrome in Premature Infant
Conditions
Brief summary
Although the pathophysiology of meconium obstruction of prematurity (MOP) is not clear, it is known that the decrease of the intestinal peristalsis due to decreased intestinal perfusion during antenatal or perinatal period. Recently, the level of citrulline has been used as an index of function and injury of the small intestine State. This study aimed to evaluate citrulline level of cord blood as a marker for early detection and observe changes in intestinal blood flow in MOP patient. And We aimed to confirm the efficacy of the AT/ET ratio (ratio of the pulmonary artery time-to-peak velocity interval to the right ventricular ejection time) of the prenatal pulmonary artery as a noninvasive predictor of neonatal respiratory distress syndrome.
Interventions
None listed
Sponsors
Seoul National University Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
No minimum to 34 Weeks
Healthy volunteers
No
Inclusion criteria
* premature infants born less than 34 weeks from mother with pregnancy induced hypertension, pre-eclampsia or eclampsia
Exclusion criteria
* major congenital anomalies * infants with hypotension while using inotropics
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Comparison of citrulline level between the meconium obstruction group and the normal feeding advance group | within 6 hours after birth | check the citrulline llevel from blood at birth |
| Comparison of prenatal AT/ET ratio of fetal pulmonary artery between respiratory distress syndrome group and the normal respiration group | within 10 days before delivery | Check the AT/ET ratio of fetal pulmonary artery within 10 days before birth |
Countries
South Korea
Outcome results
None listed