Burns
Conditions
Keywords
muscle function
Brief summary
The purpose of this study is to learn if there is a difference in recovery time when using sugammadex versus neostigmine. The researchers also hope to add further knowledge and data to the safety of using sugammadex in burn patients who are hypermetabolic.
Interventions
DRUGSugammadex
Sugammadex is indicated for the reversal of neuromuscular blockade.
DRUGNeostigmine
Neostigmine is indicated for the reversal of neuromuscular blockade.
DRUGGlycopyrrolate
Glycopyrrolate is used in conjunction with neostigmine to prevent neostigmine's muscarinic effects.
Sponsors
University of Kansas Medical Center
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Undergoing burn surgery under general anesthesia
Exclusion criteria
* Patients without a non-burned upper extremity * Renal insufficiency or failure * Sensitivity or hypersensitivity reaction to sugammadex * Liver impairment, neuromuscular degenerative disease or dependence on drugs or alcohol
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time to return to a 90% Train of Four (TOF) neuromuscular twitch | Within 24 hours after surgery |
Secondary
| Measure | Time frame |
|---|---|
| Time to endotracheal extubation | Within 24 hours after surgery |
| Time to discharge from the operating room | Within 24 hours after surgery |
Countries
United States
Outcome results
None listed