Cognitive Impairment, Traumatic Brain Injury
Conditions
Keywords
working memory, cognitive rehabilitation, functional neuroimaging
Brief summary
The aim of this study is to assess the brain correlates, as assessed with multimodal MRI, of working memory training in patients with severe traumatic brain injury (TBI)
Detailed description
This is a pilot feasibility study. Patients with subacute/chronic (\> 6 months) severe TBI will be included if they suffer from a deficit in working memory. They will receive a specific hierarchical training of working memory (3 sessions per week during three months), according to a previously described methodology. A multimodal MRI will be performed at neuroSpin center (CEA, Orsay, France) before and after cognitive training, including: structural imaging (T1, FLAIR and diffusion tensor imaging, DTI); functional connectivity at rest; and functional activation during a working memory task (n-back). Behavioral and imaging changes after training will be analysed individually and compared to a group of healthy controls matched for age, gender and education.
Interventions
BEHAVIORALworking memory training
Hierarchical cognitive training of the different components of working memory according to Baddeley model; 15 tasks are used addressing: the phonological loop (8 tasks), the visuospatial sketchpad (4 tasks) and the central executive 3 tasks). Task are given in a hierarchical order, according to each individual patient's deficits and improvement.
Sponsors
Centre d'Investigation Clinique et Technologique 805
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Intervention model description
a group of 10 patients with severe TBI will receive 3-month rehabilitation of working memory and will be compared to a group of 10 healthy controls
Eligibility
Sex/Gender
ALL
Age
18 Years to 55 Years
Healthy volunteers
Yes
Inclusion criteria
* moderate to severe traumatic brain injury * 6 months or more after the injury * working memory deficit on cognitive testing
Exclusion criteria
* previous neurological or psychiatric condition * severe behavioral troubles * contra-indication to MRI * pregnancy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| working memory questionnaire | change from baseline to 3 months | It is a self-assessment questionnaire comprising 30 questions scored on a five-point Likert scale, ranging from 0 (no problem at all) to 4 (very severe problem in everyday life). The total score will be used. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| working memory testing | change from baseline to 3 months | neuropsychological assessment of working memory |
| neuro-imaging changes | change from baseline to 3 months | multimodal 3T MRI |
Countries
France
Contacts
Primary ContactPhilippe AZOUVI, MD-PhD
Backup ContactErica VLACHOS, CRA
Outcome results
None listed