Pain, Postoperative
Conditions
Keywords
pregabalin, dexmedetomidine, postoperative pain
Brief summary
Pregabalin and dexmedetomidine have been introduced to manage postoperative pain. The present study aimed to evaluate the effect of the combination of two drugs on pain relief in patients undergoing total knee or hip arthroplasty under spinal anesthesia
Detailed description
One hundred and twenty-four patients undergoing total knee or hip arthroplasty under spinal anesthesia were randomly assigned to either group C (n = 31, placebo), group P (n = 33, pregabalin), group PD (n = 29, pregabalin and dexmedetomidine) or group D (n = 31, dexmedetomidine). One hour before spinal anesthesia, patients received pregabalin 150 mg or placebo orally and a bolus dose of 0.5 μg /kg IV dexmedetomidine was given over 10 min before induction of spinal anesthesia, followed by a continuous infusion of 0.5 μg/kg/hr or the same calculated volume of normal saline till completion of the surgery. Clinically relevant pain for 24 h after surgery including time to first analgesic request visual analog scale (VAS), ketorolac dose, and patient controlled analgesics (PCA) volume consumed were recorded.
Interventions
DRUGPregabalin
One hour before spinal anesthesia, patients received pregabalin 150 mg capsule orally and the same calculated volume of normal saline till completion of the surgery
DRUGDexmedetomidine
One hour before spinal anesthesia, patients received placebo and a bolus dose of 0.5 μg /kg IV dexmedetomidine was given over 10 min before induction of spinal anesthesia, a bolus dose of 0.5 μg /kg IV till completion of the surgery
OTHERPlacebo
One hour before spinal anesthesia, patients received placebo and the same calculated volume of normal saline till completion of the surgery
DRUGPregabalin and dexmedetomidine
One hour before spinal anesthesia, patients received pregabalin 150 mg orally and a bolus dose of 0.5 μg /kg IV dexmedetomidine was given over 10 min before induction of spinal anesthesia, a bolus dose of 0.5 μg /kg IV till completion of the surgery.
Sponsors
Wonkwang University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
19 Years to 75 Years
Healthy volunteers
Yes
Inclusion criteria
* ASA I-II * Aged 18-75 years One hundred and twenty-four patients with intact cognitive function to understand this study undergoing elective total knee or hip arthroplasty under spinal anesthesia
Exclusion criteria
* Pregnant * Allergic and/or contraindicated to the study drugs * American Society of Anesthesiologists (ASA) score III and above * Having drug * Alcohol addiction * Renal failure * Diabetes mellitus * Epilepsy * currently using opioids for chronic pain and/or any of the drugs studied.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Patient controlled analgesics (PCA) volume | For 24 hours | Patient controlled analgesics (PCA) volume consumed for 24 hours after surgery |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| time to first analgesic request | for 24 hours | time to first analgesic request for 24 hours after surgery |
| visual analog scale (VAS) | for 24 hours | The VAS consisted of a straight line with the left end of the line representing no pain and the right end of the line representing the worst pain. Patients were asked to mark the position on the line corresponding to their perception of pain. The VAS scores for pain at rest and on movement were measured at intervals of 24, and 48 hours after surgery |
| ketorolac dose | for 24 hours | ketorolac dose for 24 hours after surgery |
| adverse effects | within the first 24 hours postoperatively | Perioperative adverse effects Shivering, blurred vision, headache, dizziness, dry mouth, nausea/vomiting during the first 24 hours postoperatively |
Countries
South Korea
Outcome results
None listed