The Relationship Between the Change of Resting Energy Expenditure and Nutritional Status .

The Relationship Between the Change of Resting Energy Expenditure(REE) and Nutritional Status in Peritoneal Dialysis(PD) Patients With Peritonitis.

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03511950

Enrollment

Registered

2018-04-30

Start date

2021-04-01

Completion date

2023-10-30

Last updated

2022-09-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Nutrition, Peritonitis, Resting Energy Expenditure

Brief summary

Peritonitis is a common and devastating complication in patients on peritoneal dialysis (PD). It is a known fact that persistent inflammatory state and nutritional deterioration are closely associated with increased mortality in PD patients.And resting energy expenditure(REE) is significantly increased in acute and chronic inflammation in patients with chronic kidney disease (including dialysis patients).However,it is limited to the changing trend and duration of REE in peritonitis.Investigators hypothesize that the increase in total energy consumption resulting from the increase of REE which may accompany with decreased energy intake will lead to negative energy balance and nutritional deterioration, which may affect the prognosis of patients.Therefore,a prospective cohort study will be designed to dynamically research the change of REE accompanied with the nutrition status in peritonitis and provide the basis for peritonitis management in the future.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Inclusion criteria

* Receiving PD for\>3 months * Age between 18 and 80 years * Confirm diagnosis of peritonitis

Exclusion criteria

* Disability * Other acute complications: including systemic infections except for peritonitis, acute cardia-cerebrovascular disease in one month * Active hepatitis and musculoskeletal diseases in the past * Cancer and is treated with chemoradiotherapy within 1 year * Severe edema of the whole body or a large amount of body cavity effusion * Thyroid dysfunction * History of hormonal drugs use * During pregnancy or lactation * Mental disorder

Design outcomes

Primary

Measure	Time frame	Description
The relationship between the change of REE and the change of albumin	90 days	Method: REE, indirect calorimetry

Secondary

Measure	Time frame	Description
The relationship between the change of REE and the change of BMI	90 days	The relationship between the change of REE and the change of BMI during 90 days after peritonitis
The relationship between the change of REE and the change of handgrip strength	90 days	The relationship between the change of REE and the change of handgrip strength during 90 days after peritonitis
The relationship between the change of REE and the change of Fat mass	90 days	Method: REE, indirect calorimetry; Fat mass, Bioelectrical impedance
The relationship between the change of REE and the change of lean body mass	90 days	Method: REE, indirect calorimetry; lean body mass, Bioelectrical impedance

Other

Measure	Time frame	Description
The relationship between the change of REE and the outcome of patients	90 days or 180days	outcome including death and transfer to hemodialysis

Countries

China

Contacts

Primary ContactJie Dong

jie.dong@bjmu.edu.cn13911841538

Outcome results