Lung Diseases, Pulmonary Disease
Conditions
Keywords
inspiratory muscle training, advanced lung disease, maximal inspiratory pressure, inspiratory endurance
Brief summary
The aim of this clinical trial is to evaluate, the effects of inspiratory muscle training program in inspiratory muscle function, functional capacity, quality of life, lung function, breathing pattern and chest wall motion in patients with advanced lung disease. Patients were evaluated before the inspiratory muscle training, after 8 weeks of training and at follow-up which was performed 3 months after the end of the intervention.
Detailed description
Inspiratory Muscle Training (IMT) should be considered an additional intervention in the pulmonary rehabilitation program for patients with advanced lung disease. The aim of this study is to evaluate, the effects of inspiratory muscle training program in inspiratory muscle function, functional capacity, quality of life, lung function, breathing pattern and chest wall motion in patients with advanced lung disease. It is a quasi-experimental study with longitudinal design. Patients with advanced lung disease from the advanced lung disease and pre lung transplantation ambulatory performed home-based high intensity interval IMT for 8 weeks (two sessions per day, daily). In each session patients executed two times 30 breaths with one-minute rest between them. Resistance was set to the highest tolerable according to scores pointed by the patient on the Borg score (between 4 and 6) aiming 50% of actual pimax or higher. An experienced physiotherapist was responsible for weekly adjustments on the resistance of training as well as new assessment of maximal inspiratory pressure. Patients were evaluated before the inspiratory muscle training, after 8 weeks of training and at follow-up which was performed 3 months after the end of the intervention. Patients were evaluated by the same experienced researcher in all three moments of the study. Evaluations were performed in the Laboratory of research and evaluation of cardiorespiratory performance of Federal University of Minas Gerais.
Interventions
OTHERInspiratory Muscle Training
Breathing through a device that offers resistance during inspiration. In this study the POWERbreathe device was used (POWERbreathe® K3, HaB International Ltd, UK).
Sponsors
Conselho Nacional de Desenvolvimento Científico e Tecnológico
Fundação de Amparo à Pesquisa do estado de Minas Gerais
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior.
Federal University of Minas Gerais
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Intervention model description
All patients from the advanced lung disease and pre lung transplantation ambulatory
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* presence of inspiratory muscle weakness (Maximal Inspiratory Pressure - MIP ≤ 60 cmH2O or below the reference values proposed for the Brazilian population. * completion of a 36 sessions of PR or nonattendance in any pulmonary rehabilitation by the time of inclusion and no perspective of initiating it in the next 8 weeks. * absence of pre-existing neuromuscular, infectious, metabolic, psychiatric diseases or orthopedic problems that prevent from activities of daily living.
Exclusion criteria
* presented inspiratory muscle strength higher than 60 cmH2O or predicted value * unable to follow commands related to the measurements or to the IMT
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in Inspiratory muscle strength | Before intervention, after 8 weeks intervention and follow-up (3 months after the end of intervention) | Maximal inspiratory pressure in cmH2O |
| Change in Inspiratory Muscle Endurance | Before intervention, after 8 weeks intervention and follow-up (3 months after the end of intervention) | Inspiratory endurance time in seconds |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in chest wall motion | Before intervention, after 8 weeks intervention and follow-up (3 months after the end of intervention) | Optoelectronic plethysmography (lung volumes in liters) |
| Change in Functional Capacity (direct measure) | Before intervention, after 8 weeks intervention and follow-up (3 months after the end of intervention) | Six minutes walking distance (meters) |
| Change in Lung Function | Before intervention, after 8 weeks intervention and follow-up (3 months after the end of intervention) | Spirometry |
| Quality of life | Before intervention, after 8 weeks intervention and follow-up (3 months after the end of intervention) | Saint George Respiratory questionnaire (total score) It is a 50 questions questionnaire. Total score can go from 0 to 100. Higher scores indicate worse quality of life. |
| Change in Functional Capacity (inderect measure) | Before intervention, after 8 weeks intervention and follow-up (3 months after the end of intervention) | London chest activity of daily living scale (total score) - It evaluates the dyspnea in daily activities. Consists in a 15 questions questionnaire with scores from 0-5 in each question. Total score varies from 0 to 75, the higher the score the major the limitation on daily activities due to dyspnea. |
| Change in Breathing pattern | Before intervention, after 8 weeks intervention and follow-up (3 months after the end of intervention) | Optoelectronic plethysmography (percentage of contribution of the 3 lung compartments to ventilation) |
Countries
Brazil
Outcome results
None listed