PTSD
Conditions
Keywords
yoga, exercise, randomized controlled trial
Brief summary
Posttraumatic stress disorder (PTSD) is a major health problem for the nation's Veterans, leading to significant physical and mental health morbidity and mortality. Current empirically-supported interventions ameliorate symptoms but generally do not restore full functioning, so the development of alternative or complementary approaches is a critical need. Large numbers of Veterans are seeking out yoga as a part of their recovery plans, but there is not enough evidence to recommend yoga for treatment of PTSD. Likely reflecting this heterogeneity, evidence of yoga's efficacy is highly variable. This project aims to address this problem by comparing the effect of yoga to a matched exercise control condition. The study will also explore the mechanisms by which yoga impacts PTSD. Ultimately, the goal of this research would be to contribute to integrative care planning, whereby multiple approaches can be applied in a synergistic manner to restore wellness for Veterans affected by PTSD.
Detailed description
Posttraumatic stress disorder (PTSD) is a chronic, debilitating condition with a broad negative impact on physical and mental health functioning. Excellent, empirically-supported interventions for PTSD are readily available to Veterans, but the majority of patients who receive the best available treatments continue to have a diagnosable disorder after treatment. This suggests that complementary interventions may be useful to fully restore functioning. In addition, many patients seek alternatives to psychotherapy or pharmacotherapy. This is evident in the increasing numbers of individuals with PTSD are turning to alternative approaches. At present, however, the investigators lack a good evidence base from which to make recommendations about the use of complementary and alternative approaches. Yoga is very popular practice, touted to enhance physical, mental and spiritual well-being. Many Veterans with PTSD have turned to yoga as a part of their recovery plan, often seeking care outside the specialty mental health system. Initial evidence suggests that the practice leads to clinically significant change in symptoms, but results are yet inconclusive, particularly in Veterans. Thus, this project will provide additional data as to efficacy of yoga for Veterans PTSD. The study is a randomized controlled trial involving approximately 100 Veterans with PTSD from the San Diego area. These Veterans will be randomized to receive a manualized hatha yoga intervention or a supportive exercise control condition. Both interventions will be delivered by trained instructors via livestreaming or recorded classes over a 12-week period. Assessment of clinical outcomes and methodological variables will take place before, during, immediately after, and 3-months after the intervention. Analyses will focus on change in the intervention groups over time and the degree to which change is associated with the candidate mechanisms. Results of this study have the potential to inform the way in which yoga is delivered to Veterans as well as to increase knowledge about the underlying processes by which PTSD can be ameliorated. Given the high demand for yoga demand by individuals with PTSD and the degree to which the practice is already being provided in many clinical settings, findings from this study will be immediately relevant. Findings may also guide future research in complementary and alternative approaches by demonstrating the principle of targeting different processes of change to create an integrative care plan.
Interventions
Manualized hatha yoga
Manualized stretching and strengthening
Sponsors
Study design
Masking description
The outcome evaluator is blind to experimental condition
Intervention model description
Experimental condition: Manualized hatha yoga, a 12-session group-based yoga class led by a trained teacher Control condition: Manualized supportive physical activity, a 12-session group-based stretching and strengthening class led by a trained instructor
Eligibility
Inclusion criteria
* Veterans who have clinically meaningful PTSD symptoms
Exclusion criteria
* serious suicidality or homicidality that has required urgent or emergent evaluation or treatment within the past three months * a known, untreated substance abuse or dependence problem * inclusion is possible if there is evidence that the individual has been afforded and is complying with treatment for the substance problem * serious mental disorders, such as psychotic disorders or bipolar type I, or serious dissociative symptoms * cognitive impairment that would interfere with treatment * circumstances that lead to recurrent traumatization * e.g., engaged in a violent relationship * any medical condition for which exercise is contraindicated, including pregnancy * concurrent enrollment in any other treatment specifically targeting PTSD symptoms or in any meditative or mind-body intervention * including yoga practice \>1 class/month in the preceding 6 months
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Clinician Administered PTSD Scale for Diagnostic and Statistical Manual Version 5 (CAPS-5) | Baseline to post-treatment (approx 12 weeks) | Semi-structured clinical interview assessing severity of PTSD symptoms administered by a trained, blinded assessor. The range of scores is 0-80. Mpre-Mpost is presented, so positive numbers indicate a reduction in PTSD symptom severity from before to after the intervention. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Patient Health Questionnaire Depression Items (PHQ-9) | Baseline to post-treatment (approx 12 weeks) | Self-report measure of depressive symptoms with a range of 0-27. Mpre-Mpost is presented, so positive numbers indicate a reduction in depression severity. |
| State-Trait Anxiety Inventory, State Subscale | Baseline to post-treatment (approx 12 weeks) | Self-report measure of anxiety symptoms with state and trait subscales; state is reported. The subscale scores range from 20 to 80. Mpre-Mpost is presented, so positive numbers indicate a reduction in anxiety. |
| State-Trait Anger Expression Inventory - II (STAXI-II), State Anger Subscale | Baseline to post-treatment (approx 12 weeks) | Self-report measure of anger with three major subscales (state anger, trait anger and anger control index), which are quantified as T-scores (i.e., 50 indicates the population mean with a standard deviation of 10), calculated from published adult norms tables. Change in T-scores, Tpre-Tpost, is presented, so positive numbers indicate a reduction in anger. |
| Insomnia Severity Index | Baseline to post-treatment (approx 12 weeks) | Self-report measure of insomnia with a range of 0-28. Mpre-Mpost is presented, so positive numbers indicate a reduction in sleep disturbance. |
| Patient-Reported Outcomes Measurement Information System (PROMIS) Pain Interference 4a | Baseline to post-treatment (approx 12 weeks) | Self-report measure of pain interference, reported as a T-score (i.e., 50 indicates the population mean with a standard deviation of 10) calculated from published adult norms table. Change in T-scores, Tpre-Tpost, is presented, so positive numbers indicate a reduction in pain interference. |
Countries
United States
Participant flow
Participants by arm
| Arm | Count |
|---|---|
| Hatha Yoga 12- week group-based yoga class
Hatha yoga: Manualized hatha yoga | 67 |
| Supportive Exercise 12-week group-based stretching and strengthening class
Supportive physical activity: Manualized stretching and strengthening | 50 |
| Total | 117 |
Withdrawals & dropouts
| Period | Reason | FG000 | FG001 |
|---|---|---|---|
| Overall Study | Adverse Event | 2 | 0 |
| Overall Study | Lost to Follow-up | 3 | 4 |
| Overall Study | Withdrawal by Subject | 16 | 9 |
Baseline characteristics
| Characteristic | Hatha Yoga | Total | Supportive Exercise |
|---|---|---|---|
| Age, Continuous | 45.9 years STANDARD_DEVIATION 13.2 | 47 years STANDARD_DEVIATION 13.1 | 48.4 years STANDARD_DEVIATION 13 |
| Education College degree | 12 Participants | 23 Participants | 11 Participants |
| Education High school or GED | 16 Participants | 26 Participants | 10 Participants |
| Education Post-college | 18 Participants | 30 Participants | 12 Participants |
| Education Some college | 21 Participants | 38 Participants | 17 Participants |
| Employment Full time | 28 Participants | 45 Participants | 17 Participants |
| Employment Not in paid workforce | 22 Participants | 40 Participants | 18 Participants |
| Employment Part time | 8 Participants | 13 Participants | 5 Participants |
| Employment Unemployed | 9 Participants | 19 Participants | 10 Participants |
| Ethnicity (NIH/OMB) Hispanic or Latino | 21 Participants | 30 Participants | 9 Participants |
| Ethnicity (NIH/OMB) Not Hispanic or Latino | 44 Participants | 85 Participants | 41 Participants |
| Ethnicity (NIH/OMB) Unknown or Not Reported | 2 Participants | 2 Participants | 0 Participants |
| Martial status Divorced, separated or widowed | 16 Participants | 27 Participants | 11 Participants |
| Martial status Married, common law or permanent partner | 37 Participants | 68 Participants | 31 Participants |
| Martial status Never married | 14 Participants | 22 Participants | 8 Participants |
| Race (NIH/OMB) American Indian or Alaska Native | 2 Participants | 5 Participants | 3 Participants |
| Race (NIH/OMB) Asian | 3 Participants | 5 Participants | 2 Participants |
| Race (NIH/OMB) Black or African American | 8 Participants | 23 Participants | 15 Participants |
| Race (NIH/OMB) More than one race | 12 Participants | 16 Participants | 4 Participants |
| Race (NIH/OMB) Native Hawaiian or Other Pacific Islander | 2 Participants | 2 Participants | 0 Participants |
| Race (NIH/OMB) Unknown or Not Reported | 1 Participants | 1 Participants | 0 Participants |
| Race (NIH/OMB) White | 39 Participants | 65 Participants | 26 Participants |
| Sex: Female, Male Female | 24 Participants | 41 Participants | 17 Participants |
| Sex: Female, Male Male | 43 Participants | 76 Participants | 33 Participants |
Adverse events
| Event type | EG000 affected / at risk | EG001 affected / at risk |
|---|---|---|
| deaths Total, all-cause mortality | 0 / 67 | 0 / 50 |
| other Total, other adverse events | 25 / 67 | 29 / 50 |
| serious Total, serious adverse events | 2 / 67 | 1 / 50 |
Outcome results
Clinician Administered PTSD Scale for Diagnostic and Statistical Manual Version 5 (CAPS-5)
Semi-structured clinical interview assessing severity of PTSD symptoms administered by a trained, blinded assessor. The range of scores is 0-80. Mpre-Mpost is presented, so positive numbers indicate a reduction in PTSD symptom severity from before to after the intervention.
Time frame: Baseline to post-treatment (approx 12 weeks)
Population: Differs from the total population due to missing data. Includes individuals with both time points because of the nature of the change score.
| Arm | Measure | Value (MEAN) | Dispersion |
|---|---|---|---|
| Hatha Yoga | Clinician Administered PTSD Scale for Diagnostic and Statistical Manual Version 5 (CAPS-5) | 3.92 change in units on a scale | Standard Deviation 10.05 |
| Supportive Exercise | Clinician Administered PTSD Scale for Diagnostic and Statistical Manual Version 5 (CAPS-5) | 3.46 change in units on a scale | Standard Deviation 10.55 |
Insomnia Severity Index
Self-report measure of insomnia with a range of 0-28. Mpre-Mpost is presented, so positive numbers indicate a reduction in sleep disturbance.
Time frame: Baseline to post-treatment (approx 12 weeks)
Population: Differs from the total population due to missing data. Includes individuals with both time points because of the nature of the change score.
| Arm | Measure | Value (MEAN) | Dispersion |
|---|---|---|---|
| Hatha Yoga | Insomnia Severity Index | 2.73 change in units on a scale | Standard Deviation 4.24 |
| Supportive Exercise | Insomnia Severity Index | 1.64 change in units on a scale | Standard Deviation 4.94 |
Patient Health Questionnaire Depression Items (PHQ-9)
Self-report measure of depressive symptoms with a range of 0-27. Mpre-Mpost is presented, so positive numbers indicate a reduction in depression severity.
Time frame: Baseline to post-treatment (approx 12 weeks)
Population: Differs from the total population due to missing data. Includes individuals with both time points because of the nature of the change score.
| Arm | Measure | Value (MEAN) | Dispersion |
|---|---|---|---|
| Hatha Yoga | Patient Health Questionnaire Depression Items (PHQ-9) | 3.79 change in units on a scale | Standard Deviation 6.01 |
| Supportive Exercise | Patient Health Questionnaire Depression Items (PHQ-9) | 2.11 change in units on a scale | Standard Deviation 4.47 |
Patient-Reported Outcomes Measurement Information System (PROMIS) Pain Interference 4a
Self-report measure of pain interference, reported as a T-score (i.e., 50 indicates the population mean with a standard deviation of 10) calculated from published adult norms table. Change in T-scores, Tpre-Tpost, is presented, so positive numbers indicate a reduction in pain interference.
Time frame: Baseline to post-treatment (approx 12 weeks)
Population: Differs from the total population due to missing data. Includes individuals with both time points because of the nature of the change score. Loss of data increased as scale is invalid if all items are not answered.
| Arm | Measure | Value (MEAN) | Dispersion |
|---|---|---|---|
| Hatha Yoga | Patient-Reported Outcomes Measurement Information System (PROMIS) Pain Interference 4a | 0.8 change in T-score | Standard Deviation 8.47 |
| Supportive Exercise | Patient-Reported Outcomes Measurement Information System (PROMIS) Pain Interference 4a | 0.92 change in T-score | Standard Deviation 6.05 |
State-Trait Anger Expression Inventory - II (STAXI-II), State Anger Subscale
Self-report measure of anger with three major subscales (state anger, trait anger and anger control index), which are quantified as T-scores (i.e., 50 indicates the population mean with a standard deviation of 10), calculated from published adult norms tables. Change in T-scores, Tpre-Tpost, is presented, so positive numbers indicate a reduction in anger.
Time frame: Baseline to post-treatment (approx 12 weeks)
Population: Differs from the total population due to missing data. Includes individuals with both time points because of the nature of the change score.
| Arm | Measure | Value (MEAN) | Dispersion |
|---|---|---|---|
| Hatha Yoga | State-Trait Anger Expression Inventory - II (STAXI-II), State Anger Subscale | 1.02 change in T-score | Standard Deviation 9.65 |
| Supportive Exercise | State-Trait Anger Expression Inventory - II (STAXI-II), State Anger Subscale | 1.08 change in T-score | Standard Deviation 6.94 |
State-Trait Anxiety Inventory, State Subscale
Self-report measure of anxiety symptoms with state and trait subscales; state is reported. The subscale scores range from 20 to 80. Mpre-Mpost is presented, so positive numbers indicate a reduction in anxiety.
Time frame: Baseline to post-treatment (approx 12 weeks)
Population: Differs from the total population due to missing data. Includes individuals with both time points because of the nature of the change score.
| Arm | Measure | Value (MEAN) | Dispersion |
|---|---|---|---|
| Hatha Yoga | State-Trait Anxiety Inventory, State Subscale | 0.23 change in units on a scale | Standard Deviation 5.61 |
| Supportive Exercise | State-Trait Anxiety Inventory, State Subscale | -0.53 change in units on a scale | Standard Deviation 6.9 |