Chinese EOPD Registry

The Chinese Early-onset Parkinson's Disease Registry

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03508960

Enrollment

3000

Registered

2018-04-26

Start date

2017-02-01

Completion date

2027-02-01

Last updated

2018-05-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Parkinson Disease

Brief summary

The purpose of the Chinese Early-onst Parkinson's disease Registry (CEOPDR) is to develop a database of persons with early-onset Parkinson's disease (EOPD) in China.

Detailed description

Parkinson's disease (PD) is the second most common disorder among degenerative neurological disease. Early-onset PD (EOPD) has its unique clinical feature and genetic basis.Investigators aim to establish a database of EOPD,and characterize the clinical feature, genetic basis, environmental factors and their interactions EOPD in China. Method: 1. Clinical feature will be measured by scales and neurological tests.Standard scales includes: Unified Parkinson's Disease Rating Scale(UPDRS), Hoehn-Yahr stages, NMSS, MMSE, PDSS(Parkinson disease sleep scales),Rapid Eye Movement Sleep Behaviour Disorder Questionnaire(RBDQ-HK),ESS(Epworth Sleepiness Scale),Rome III functional constipation scale，SCOPA-AUT (the Scale for Outcomes in PD for Autonomic Symptoms)，PFS(Parkinson Fatigue Scale)，CH-RLSq，Hyposmia rating scale(HRS)HAMILT depression scale，the 39-item Parkinson's Disease Questionnaire(PDQ-39)，Freezing of gait scale(FOG)，dyskinesia related scales, Wearing-off scale(WO) 2. Peripheral blood from patients was collected for whole exome sequencing. 3. The environmental factors are explored by questionnaires including smoking,drinking, pesticide and heavy metals.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

No minimum to 50 Years

Healthy volunteers

Inclusion criteria

* Patients diagnosed with PD by UKBB and other standard criteria Age of onset is no more than 50 years old.

Exclusion criteria

* Patients have a family history of PD.

Design outcomes

Primary

Measure	Time frame	Description
Database of Early-onset Parkinson's Disease	10 years	To collect 3000 patients with early-onset parkinson's disease and establish the database of early-onset Parkinson's disease in mainland China.
Risk Factors	10 years	To characterize clinical feature and environmental factors among Chinese early-onset parkinson's disease
Genetic Basis	10 years	To characterize the genetic basis of Chinese EOPD and detect clinically relevant genetic variants in these cases.

Countries

China

Contacts

Primary ContactJ Guo, Ph.D.

guojifeng2003@163.com+8613974936815

Backup ContactBeisha Tang, Ph.D.

bstang7398@163.com+8613974856709

Outcome results