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Effect of Patient Position on Arterial, End-tidal and Transcutaneous Carbon Dioxide

Effect of Patient Position on Arterial, End-tidal and Transcutaneous Carbon Dioxide Partial Pressure in Patients Undergoing Laparoscopic Surgery

Status
UNKNOWN
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT03508791
Enrollment
142
Registered
2018-04-26
Start date
2018-05-20
Completion date
2019-04-30
Last updated
2018-05-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ventilation Perfusion Mismatch

Brief summary

Investigators evaluate the effect of patient position (Trendelenburg and reverse Trendelenburg) on arterial, end-tidal and transcutaneous carbon dioxide partial pressure in patients undergoing laparoscopic surgery.

Detailed description

Investigators evaluate the effect of patient position (Trendelenburg and reverse Trendelenburg) on arterial, end-tidal and transcutaneous carbon dioxide partial pressure in patients undergoing laparoscopic surgery. Arterial carbon dioxide partial pressure is assessed intermittently before, during, and after pneumoperitoneum. End-tidal and transcutaneous carbon dioxide partial pressure are continuously monitored.

Interventions

OTHERArterial carbon dioxide monitoring

Arterial carbon dioxide partial pressure is monitored during the laparoscopic surgery undergoing in the Trendelenburg or reverse Trendelenburg positions.

OTHEREnd-tidal carbon dioxide monitoring

End-tidal carbon dioxide partial pressure is monitored during the laparoscopic surgery undergoing in the Trendelenburg or reverse Trendelenburg positions.

OTHERTranscutaneous carbon dioxide monitoring

Transcutaneous carbon dioxide partial pressure is monitored during the laparoscopic surgery undergoing in the Trendelenburg or reverse Trendelenburg positions.

Sponsors

SMG-SNU Boramae Medical Center
Lead SponsorOTHER

Study design

Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
DOUBLE (Subject, Outcomes Assessor)

Eligibility

Sex/Gender
ALL
Age
20 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* adult patients undergoing laparoscopic surgery (expected duration of pneumoperitoneum \> 1 hour) in the Trendelenburg or reverse Trendelenburg positions

Exclusion criteria

* hemodynamically unstable patients due to decompensated heart failure, sepsis, or symptomatic arrhythmia, etc. * symptomatic pulmonary disease, chronic obstructive pulmonary disease

Design outcomes

Primary

MeasureTime frameDescription
Difference between arterial and end-tidal carbon dioxide pressuresbaseline before CO2 pneumoperitoneum, every 30 minute during CO2 pneumoperitoneum, and 15 min after deflation of CO2Difference between arterial and end-tidal carbon dioxide partial pressures are calculated. (Arterial carbon dioxide partial pressure minus end-tidal carbon dioxide partial pressure)

Secondary

MeasureTime frameDescription
Agreement among arterial, end-tidal, and transcutaneous carbon dioxide partial pressurebaseline before CO2 pneumoperitoneum, every 30 minute during CO2 pneumoperitoneum, and 15 min after deflation of CO2Arterial, end-tidal, and transcutaneous carbon dioxide partial pressures are recorded and the agreement among the values is analyzed using the statistical test.

Contacts

Primary ContactJin-Young Hwang, MD.Ph.D.
mistyblue15@naver.com82-2-870-2518

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026