Sclerosis, Multiple
Conditions
Brief summary
It's a pilot, interventional prospective monocentric study. It aims to compare the wall / lumen ratio (WLR) of retinal arterioles (common marker of microangiopathies) between patients with multiple sclerosis and controls using the technique of adaptive optics.
Interventions
OTHEROcular fundus on patient with Multiple Sclerosis
Ocular fundus on patient with Multiple Sclerosis
OTHEROcular Fundus on voluntary person
Ocular Fundus on voluntary person
Sponsors
Versailles Hospital
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
Patient Inclusion Criteria * Major patient between 18 and 50 years * Patient with relapsing or remitting multiple sclerosis defined according to revised Mc Donald criteria 2010 * Written, free and informed consent dated and signed * Patient affiliated to a social security scheme Control Inclusion Criteria: * Person between the ages of 18 and 50 * Written, free and informed consent dated and signed * Person affiliated to a social security scheme * Person with multiple sclerosis
Exclusion criteria
* Contraindication to the use oxygen (O2): Acute or chronic respiratory insufficiency * Pregnant or lactating woman * Inability to see fundus (cataract), retinopathy, glaucoma * Use of vasoactive substances (eg nasal decongestants, triptans, alkaloids) in the last 48 hours * Use of nonsteroidal anti-inflammatory drugs (ibuprofen, naproxen, ..) and steroids (corticosteroids) in the last 48 hours * Known Diabetes or taking antidiabetics in the last 48 hours * Use of statins in the last 48 hours * Known hypertension or antihypertensive treatment in the last 48 hours * Any cardiac pathology (valvulopathy, angina, ventricular arrhythmia or atrial fibrillation), vascular (arteritis obliterating the lower limbs, stenosis of the arteries with encephalic destiny, coronary artery disease) or significant respiratory (asthma, Chronic obstructive pulmonary disease, interstitial pathology) * Alcohol consumption within 8 hours * Ophthalmoparesis or incapacitating nystagmus (impossibility of correctly evaluating the fundus)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare the wall / lumen ratio (WLR) of retinal arterioles (common marker of microangiopathies) between multiple sclerosis patients and controls using the adaptive optics technique. | Day 0 |
Secondary
| Measure | Time frame |
|---|---|
| Compare between patients with multiple sclerosis and controls, retinal arteriolar gauges measured by external and internal diameter. | Day 0 |
| Correlate possible changes in arteriolar WLR with internal and external diameter, smoking, age, blood pressure, fatigue (MFIS), cognition (MDT) and disability (EDSS) scores to ambient air and normobaric oxygen. | Day 0 |
Countries
France
Outcome results
None listed