Periodontal Diseases
Conditions
Brief summary
The primer aim of the study was to investigate saliva and gingival crevicular fluid (GCF) YKL-40 and also interleukin-6 (IL-6) levels in chronic periodontitis pathogenesis.
Detailed description
This study consisted of two groups: 26 periodontally healthy individuals and 26 generalized chronic periodontitis patients. Chronic periodontitis patients were received nonsurgical periodontal treatment. Clinical measurements were recorded, saliva and GCF samples were obtained before and at first and third months after periodontal therapy. Levels of YKL-40 and IL-6 in saliva and GCF were analyzed by enzyme-linked immunosorbent assay.
Interventions
PROCEDURENonsurgical periodontal therapy
Nonsurgical periodontal therapy includes oral hygiene education and scaling and root planning approaches to eliminate microbial dental plaque that is the primary etiology of periodontal diseases.
Sponsors
Zeynep Pinar KELES
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
26 Years to 49 Years
Healthy volunteers
Yes
Inclusion criteria
Group 1 Inclusion Criteria: * No bone and attachment loss, * GI=0, PPD≤3mm, CAL≤3mm * Systematically healthy patients Group 2 Inclusion Criteria: * GI\>1, PPD≥5mm, CAL≥5mm with alveolar bone loss radiographically. * Systematically healthy patients
Exclusion criteria
* Aggressive Periodontitis, * Patients with any other systemic diseases, * Pregnant women and those in the lactation period, * Patients with smoking habit and taking medication * Patients received periodontal therapy in last 6 month
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| YKL-40 levels | at first and third month after therapy | changes in YKL-40 levels after periodontal therapy |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| IL-6 levels | at first and third month after therapy | changes in IL-6 levels after periodontal therapy |
Outcome results
None listed