Retrobulbar Block Versus Ketamine Infusion for Post-enucleation Analgesia

Retrobulbar Block Versus Ketamine Infusion as Adjuvants to General Anesthesia for Post-operative Pain Control After Enucleation

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03507426

Enrollment

Registered

2018-04-25

Start date

2018-04-25

Completion date

2020-03-31

Last updated

2020-07-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Enucleated; Eye, Evisceration; Operation Wound, Pain, Postoperative

Keywords

Retrobulbar block, Ketamine, Ocular enucleation, Analgesia

Brief summary

This study compares the efficacy and safety of two techniques, retrobulbar block versus intra-operative ketamine infusion, for control of post-operative pain occurring in patients undergoing ocular enucleation or evisceration performed under general anesthesia.

Interventions

PROCEDURERetrobulbar block

Patients will receive a single retrobulbar injection with 3-4ml of an equal mixture of Lidocaine 2% & Bupivacaine 0.5% + Hyaluronidase (10 IU/ml), after induction of general anesthesia.

PROCEDUREKetamine

Patients will receive a 0.5 mg/kg bolus followed by an infusion of 0.25 mg/kg/h of intravenous Ketamine, after induction of general anesthesia.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

SUPPORTIVE_CARE

Masking

DOUBLE (Subject, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Ocular enucleation candidate patients * Ocular evisceration candidate patients

Exclusion criteria

* Any condition contra-indicating general or local anesthesia * Allergy to any of the drugs used during the procedure

Design outcomes

Primary

Measure	Time frame	Description
Time to the first post-operative rescue analgesia.	24 hours	Time (measured in minutes) elapsed till the patient requires to receive his first post-operative rescue analgesic dose.

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026