Infertility
Conditions
Keywords
texturization, pregnancy rate, oocyte donation, 2D ultrasound, 3D ultrasound, assisted reproductive technology (ART)
Brief summary
This study is focused on analysing the application of ultrasound scanning techniques as new biomarkers in reproductive medicine. Those biomarkers are based on the analysis of ultrasound texture in different areas of uterine tissue, using 2D/3D ultrasound scanning. Investigators will use the algorithm Text® to analyse the ultrasound texture of the endometrium and myometrium. The aim of the project is to study if it is possible to obtain measurable, objective and reproducible data in healthy volunteers which can be used to predict pregnancy and determine the best moment to perform embryo transfer in assisted reproductive technology (ART) cycles
Interventions
OTHERUltrasound texturization
Along several visits to the clinic, the patients will be subjected to 2D/3D ultrasound scanning.
Sponsors
Vida Recoletas Sevilla
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 49 Years
Healthy volunteers
No
Inclusion criteria
* Body mass index (BMI) between 18 and 30 kg/m2 * Not taking the contraceptive pill in a previous cycle * Non-pregnant: beta human chorionic gonadotropin (HCG) test with negative result at the beginning of the study) * No previous history of inflammatory diseases, circulatory diseases, abdomen or pelvic diseases * Physical gynecological exploration without pathological findings * Gynecological ultrasound study of the uterus with a normal result
Exclusion criteria
* Ultrasound studies with technical defects in image acquisition * Simultaneous participation in other studies * Previous participation in other study which can affect the results of the present study
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Clinical pregnancy rate | Around 5-6 weeks after embryo transfer | Detection of gestational sac through ultrasound scanning indicating clinical pregnancy |
| Biochemical miscarriage rate | Up to one month after embryo transfer | Interruption of pregnancy after a positive result in the beta HCG test |
| Clinical miscarriage rate | Up to 20 weeks after embryo transfer | Interruption of pregnancy after confirming clinical pregnancy using ultrasound scanning |
| Chemical pregnancy rate | Around 14 days after embryo transfer | Positive result in beta HCG test indicating pregnancy |
| beta HCG level | Around 14 days after embryo transfer | Level of beta HCG in the test performed to detect pregnancy |
Countries
Spain
Outcome results
None listed