Blood, Muscle and Exercise Responses to Sodium Bicarbonate Supplementation

Blood and Muscle Responses to Sodium Bicarbonate Supplementation and Subsequent Exercise Performance

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03505970

Enrollment

Registered

2018-04-23

Start date

2019-08-31

Completion date

2020-12-31

Last updated

2019-06-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sports Nutritional Physiological Phenomena

Keywords

Physiological Phenomena

Brief summary

The aim of this study is to evaluate the changes in activity of transporters of H+ (monocarboxylate transporters; MCT1, MCT4, NHE) following sodium bicarbonate supplementation and subsequent exercise performance. Fifteen healthy men (age 18-35 years) will be invited to attend the laboratory on five separate visits to a randomized, double-blind, placebo-controlled study. Participants will be supplemented with a 0.3 g/kg dose of sodium bicarbonate or placebo (Analytical Pharmacy, Brazil) in opaque gelatin capsules. One hour after supplementation they will perform a 1-km time trial and every 10 minutes a blood sample will be collected. A muscle biopsy will be taken prior to supplementation, immediately prior to exercise, and immediately post-exercise. A questionnaire will be also used to evaluate the side-effects associated with sodium bicarbonate supplementation. Muscle and blood samples will be analysed for acidity and H+ and muscle samples will be analysed for H+ transporters (MCT1, MCT4, NHE).

Interventions

DIETARY_SUPPLEMENTSodium bicarbonate

Sodium bicarbonate in powder form ingested in gelatine capsules. This leads to an increase bicarbonate concentration in blood, increasing buffering capacity which may lead to improvements in exercise

DIETARY_SUPPLEMENTMaltodextrin

Maltodextrin will be used as a placebo as it will not lead to any increases in circulating bicarbonate and, at this dose, will not likely have any physiological effect.

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

OTHER

Masking

TRIPLE (Subject, Investigator, Outcomes Assessor)

Intervention model description

Double-blind crossover

Eligibility

Sex/Gender

MALE

Age

18 Years to 35 Years

Healthy volunteers

Yes

Inclusion criteria

* Healthy males

Exclusion criteria

* Smokers * Chronic disease * Prior or current use of steroids * Use of creatine in the last 6 months * Use of beta-alanine in the last 6 months

Design outcomes

Primary

Measure	Time frame	Description
H+ transporter activity	5 minutes Post-exercise	Change in activity of transporters related to H+

Secondary

Measure	Time frame	Description
Exercise performance	1 hour Post-supplementation	Change in 1 km cycling time-trial performance

Contacts

Primary ContactBruno Gualano, PhD

gualano@usp.br3061-8789

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026