Antiphospholipid Syndrome in Pregnancy
Conditions
Brief summary
Antiphospholipid antibodies are autoantibodies directed against phospholipid-binding proteins. Among these groups of antibodies, lupus anticoagulant (LA) and anticardiolipin antibodies (aCL)
Detailed description
APLS can be primary when no evidence of autoimmune disease is found, or secondary to autoimmune processes like systemic lupus erythematous (SLE) in a 40% of the cases.
Interventions
DIAGNOSTIC_TESTUltrasound with Doppler and 3D technology
ultrasound will be made to pregnant females in 3rd trimester with doppler and 3D technology
Sponsors
Cairo University
Aljazeera Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* Singleton pregnancy. * Gestational age of 34-37 weeks. * Pregnant women with antiphospholipid syndrome
Exclusion criteria
* Twin or multiple pregnancies. * Congenital fetal anomalies. * Gestational age of less than 34. * Gestational age of more than 37. * Women with placental or umbilical artery anomalies. * Antepartum hemorrhage (placental abruption, placenta previa and vasa previa). * Posterior placenta. * History of rupture of membrane. * Patient refusal or fall outs.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The number of participants who will have impaired placental doppler indices | within 2 months |
Countries
Egypt
Contacts
Primary ContactMahmoud Alalfy
Outcome results
None listed