Skin Manifestations, Skin Wrinkling
Conditions
Brief summary
Comparison of a randomized, double-blind, and control-group study for the effect of oral ingestion of collagen tripeptides derived from fish on dermal moistures and wrinkles body fat reduction in participants
Detailed description
The aim is to investigate the effect of oral ingestion of collagen tripeptides derived from fish on dermal moistures and wrinkles body fat reduction in participants by a randomized, double-blind, and control-group study.
Interventions
DIETARY_SUPPLEMENTCTP
1,000 mg of CTP was orally administered per day for 12 weeks.
DIETARY_SUPPLEMENTplacebo (starch)
placebo (starch)
Sponsors
Pusan National University Yangsan Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
TRIPLE (Subject, Caregiver, Investigator)
Eligibility
Sex/Gender
FEMALE
Age
40 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
\- \> = 4 of Tewameter
Exclusion criteria
* Within the last 6 months, took skin surgery including cosmetic purpose * Diabetic patients with poor glycemic control with a fasting blood glucose of 160 mg/dl or more * Creatinine levels: more than twice the normal upper limit * AST (GOT) or ALT (GPT) levels: more than twice the normal upper limit * Uncontrolled hypertension * sun allergy or sensitive skin * functional cosmetics that affect dermal moistures and wrinkles within the last 3 months. * If you have participated or are planning to participate in another clinical trial within the past month * Alcohol abuser * If they are pregnant or lactating or have a pregnancy plan during the clinical trial Those with allergic reactions to the constituent food * Any person deemed inappropriate by the researcher for other reasons
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| changes in Transepidermal Waterloss by Tewameter | baseline, after 6 weeks, and after 12 weeks | comparison between baseline, after 6 weeks, and after 12 weeks |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| changes in skin wrinkling indices by Visiometer | baseline, after 6 weeks, and after 12 weeks | comparison between baseline, after 6 weeks, and after 12 weeks |
| skin elasticity by Cutometer | baseline, after 6 weeks, and after 12 weeks | comparison between baseline, after 6 weeks, and after 12 weeks |
| changes in hydration level of the skin surface by Corneometer | baseline, after 6 weeks, and after 12 weeks | comparison between baseline, after 6 weeks, and after 12 weeks |
Countries
South Korea
Outcome results
None listed