GDM, Myometrium; Contractility, Obesity
Conditions
Brief summary
Investigate the effect of two adipokines which are adiponectin and TNFa on the force of myometrial contractility in diabetic, non-obese pregnant women and obese, non-diabetic term pregnant women at the time of scheduled cesarean delivery
Interventions
BIOLOGICALAdiponectin and TNFa
Adiponectin and TNFa are adipokines. Will be added to the myometrial biopsies to investigate their effect on the force of contractility
Sponsors
University of Minnesota
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 55 Years
Healthy volunteers
Yes
Inclusion criteria
* Pregnant patients scheduled for a CS at 37-41 weeks of gestation at M Health Birth Place * Participants age ≥18. * Full informed consent able to be provided by the participant.
Exclusion criteria
* Patients undergoing general anesthesia for their CS. * Pre-gestational DM, and DM diagnosed \<24 weeks gestation. * Patients unable to consent for themselves * Multiple gestation
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Effect on force of contractility | 24 hours | Determine the effect of adiponectin and TNFa on the force of myometrial contractility in diabetic, non-obese pregnant women and obese, non-diabetic term pregnant women at the time of scheduled cesarean delivery |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Force of contractility between study groups | 24 hours | Compare the force of myometrial contractility in study groups compared to control group (non-DM, non-obese term pregnant patients) |
| Progesterone effect in control group | 24 hours | Investigate the anti-inflammatory properties of Progesterone (P4) and 17a-Hydroxyprogesterone (HPC) on Adiponectin induced myometrial contractility in control group |
Countries
United States
Outcome results
None listed