Pain, Parkinson Disease
Conditions
Keywords
deep repetitive transcranial magnetic stimulation, chronic pain, parkinson, treatment, non-motor symptom
Brief summary
Pain is the most prevalent non-motor symptom in Parkinson disease, and the motor improvement not always is related to the pain improvement with the medication treatment. By this, we are testing a non-invasive method called transcranial magnetic stimulation as an alternative to treat pain related to Parkinson disease. This technique can lead to either inhibitory or excitatory effects in brain circuits depending on stimulation parameters, and is known to provide analgesic effects.
Interventions
DEVICEdeep rTMS
DEVICEplacebo deep rTMS
Sponsors
University of Sao Paulo
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Parkinson disease * Signed term of informed consent * Parkinsson disease related pain
Exclusion criteria
* Trauma of Skull, epilepsy don't treated * Use of medications decrease the seizure threshold * Patients in use of drugs, how cocaine and alcohol * neurosurgical clips, pacemakers, increased intracranial pressure (risk of sequelae after seizure) * Pregnant or lacting women * Moderate or severe cognitive impairment
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in baseline of Pain | base line (moment of inclusion), day 15th, day 45th and in the last day of the sessions of rTMS (4X in two months) | assessing by Visual Analog Scale for Pain (VAS). This scale range from 0 (no pain) to 10 (maximum pain), being considered an effective improvement in the patient's pain when the pain decreases at least in 30% from the basal score. |
Countries
Brazil
Contacts
Primary ContactDaniel MD Ciampi, Phd
Backup ContactVictor MD Barboza, PhD student
Outcome results
None listed