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Influence of Different Anesthetic Procedures on Sleep Disorder Breathing

Influence of Different Anesthetic Procedures on Sleep Disorder Breathing in Adult Patients Undergoing Elective Surgery

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT03499132
Enrollment
90
Registered
2018-04-17
Start date
2018-03-01
Completion date
2020-03-01
Last updated
2020-03-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obstructive Sleep Apnea

Keywords

anesthesia, obstructive sleep apnea

Brief summary

Obstructive sleep apnea (OSA) is a common form of sleep disordered breathing characterized by partial or complete upper airway obstructions during sleep. OSA is associated with major comorbidities and perioperative complications. These complications are caused not only by the OSA itself, but also by exacerbations of this syndrome during the perioperative period (1). Benzodiazepines, volatile anesthetics and opioids may lead to lower hypoxia and hypercapnia sensitivity and may cause respiratory depression (2-5). Therefore, preference of neuraxial blockades and avoidance of opioids has been suggested for patients with OSA (6). However, there is still lack of evidence to evaluate the effects of various anesthesia procedures on OSA (6,7). We hypothesize different anesthetic procedures will have different effect on OSA exacerbations in the postoperative period. Accordingly, the aim of this study is to compare the number of sleep disordered breathing episodes in the postoperative period in patients with different anesthetic procedures.

Interventions

PROCEDUREanesthesia

Different anesthetic procedures

Sponsors

St. Anne's University Hospital Brno, Czech Republic
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
18 Years to 100 Years

Inclusion criteria

* elective orthopedic surgery

Exclusion criteria

* already diagnosed sleep disorder breathing * continuous positive airway pressure therapy * tracheostomy * American Society of Anesthesiologists class IV-V

Design outcomes

Primary

MeasureTime frameDescription
Apnea-hypopnea index change4 nights after surgeryChanges (post-pre) in apnea-hypopnea index 4 nights post surgery

Countries

Czechia

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026