Cardiovascular Complication, Pulmonary Complication
Conditions
Keywords
cardiopulmonary exercise testing, thoracic surgery
Brief summary
Cardiopulmonary exercise testing is recommended for preoperative evaluation and risk stratification of lung resection candidates. Ventilatory efficiency (VE/VCO2 slope) has been shown to predict morbidity and mortality in lung resection candidates and has been shown superior to peak oxygen consumption (VO2). Patients with increased VE/VCO2 during exercise also exhibit increased VE/VCO2 ratio and decreased end-tidal CO2 at rest. Our first hypothesis is that rest ventilatory parameters predict morbidity and mortality in patients undergoing thoracic surgery. VE/VCO2 is well correlated with ventilation-perfusion mismatch, therefore it may be useful in hypoxemia prediction during one-lung ventilation during thoracic surgery. Our second hypothesis is that patients with high VE/VCO2 will be prone to hypoxemia development during one-lung ventilation.
Interventions
PROCEDUREThoracic surgery
Lung resection surgery
Sponsors
St. Anne's University Hospital Brno, Czech Republic
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 100 Years
Healthy volunteers
No
Inclusion criteria
* thoracotomy because of lung infiltration (confirmed or highly suspicious lung tumor)
Exclusion criteria
* none
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Pulmonary complications | Respiratory complications will be assessed from the first 30 post-operative days or from the hospital stay. | Respiratory complications definition: pneumonia, atelectasis; respiratory failure needing mechanical ventilation; adult respiratory distress syndrome; pneumothorax present on the 3rd post-operative day; long-lasting pleural effusions present on the 3rd post-operative day |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Intensive care length of stay | From the first 30 post-operative days or from the hospital stay. | In all subjects, intensive care unit length of stay will be assessed. |
| Hospital length of stay | From the first 30 post-operative days or from the hospital stay. | In all subjects, hospital length of stay will be assessed. |
| Cardiovascular complications | Cardiovascular complications will be assessed from the first 30 post-operative days or from the hospital stay. | Cardiovascular complications definition: new arrhythmias (atrial fibrillation, supraventricular tachycardia, etc.); hypotension; heart failure; pulmonary edema; pulmonary embolism; myocardial infarction/minimal myocardial lesion; cardiopulmonary resuscitation |
| Mortality | 30 and 90 days after surgery. | In all subjects, 30 and 90 days mortality will be assessed. |
Countries
Czechia
Outcome results
None listed