Laparoscopic Gynecologic Surgery
Conditions
Keywords
sevoflurane, propofol, intracranial pressure, optic nerve sheath diameter
Brief summary
Intracranial pressure（ICP) increases during laparoscopic gynecologic surgery increase (ICP) and may alter optic nerve sheath diameter(ONSD).This study measures ONSD in different team because sevoflurane and propofol have different effects on ICP.Half of participants will receive sevoflurane anesthesia,while the other half undergo propofol anesthesia.
Detailed description
Due to the anatomical and physiological characteristics of optic nerve sheath ,ONSD increases when ICP rises. Sevoflurane and propofol have different effects on ICP.When sevoflurane concentration \>1.1 minimum alveolar concentration（MAC),ICP increases because of cerebral vasodilatation；on the other hand ,propofol constricts the blood vessels and ICP decreases. ICP increases during laparoscopic gynecologic surgery because of steep Trendelenburg position and pneumoperitoneum . Meanwhile,sevoflurane affects self regulation of cerebral blood flow on the way of dose dependent,but propofol has no effects on self regulation of cerebral blood flow.
Interventions
DRUGSevoflurane
In Team Sevoflurane,patients undergo sevoflurane.
DRUGPropofol
In Team Propofol ,anesthesia is maintained with propofol
Sponsors
Obstetrics & Gynecology Hospital of Fudan University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* American Society of Anesthesiologists physical status diagnosed as I or II
Exclusion criteria
* neuromuscular diseases;laboratory abnormalities in electrolytes; liver and kidney dysfunction;allergy to general anesthetics;pregnancy;ocular lesions including ocular trauma, optic neuritis, optic nerve tumor.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Changes of ultrasonographic optic nerve sheath diameter | from the time when patients enter into operation room to the time when the surgery ending | different time including pre-anesthesia, after intubation,every 15 minutes in the first hour after beginning of surgery, every hour when one hour after surgery beginning,surgery ending. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Analyzed whether mean arterial pressure influence the change of ONSD based on 110 patients in two groups. | from the time when patients enter into operation room to the time when the surgery ending | Mean arterial pressure was collected when measures ONSD by ultrasound. |
| Analyzed whether airway pressure influence the change of ONSD based on 110 patients in two groups. | from the time when patients enter into operation room to the time when the surgery ending | airway pressure was collected when measures ONSD by ultrasound. |
| Analyzed whether urine volume influence the change of ONSD based on 110 patients in two groups. | from the time when patients enter into operation room to the time when the surgery ending | Recording urine volume when the surgery finished. |
| Analyzed whether blood loss influence the change of ONSD based on 110 patients in two groups. | from the time when patients enter into operation room to the time when the surgery ending | Recording blood loss when the surgery finished. |
| Analyzed whether fluid volume influence the change of ONSD based on 110 patients in two groups. | from the time when patients enter into operation room to the time when the surgery ending | Recording fluid volume when the surgery finished. |
Countries
China
Outcome results
None listed