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Diagnosis of Acquired Punctal Stenosis Using Anterior Segment Optical Coherence Tomography

Evaluation of Acquired Punctal Stenosis by Using Anterior Segment Optical Coherence Tomography (AS-OCT)

Status
UNKNOWN
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT03498144
Enrollment
60
Registered
2018-04-13
Start date
2018-05-01
Completion date
2018-07-01
Last updated
2018-04-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Punctal Stenosis

Keywords

acquired punctal stenosis, epiphora, lower punctum, AS-OCT

Brief summary

Purpose of the study To evaluate the lower puntum dimensions in cases of acquired punctal stenosis(APS), using anterior segment optical coherence tomography (AS-OCT).

Detailed description

(B)Examination: 1. External examination: should be done to rule out causes of watering other than punctal stenosis (facial palsy, lacrimal pump failure, swelling in lacrimal sac area and regurge test) 2. Slit lamp examination: for tear meniscus, lid margin, conjunctiva and punctual orifice 3. Fluorescein dye disappearance test: performed with a drop of 2% fluorescein in lower conjunctival sac, patient is instructed not to wipe the eyes. After 5 minutes, presence of staining in the tear film is assessed with cobalt blue filter. 4. Probing and lacrimal syringing, if patent confirms punctal stenosis to be the cause of epiphora rather than block in the lower lacrimal drainage system. 5. Anterior segment optical coherence tomography examination (AS-OCT) for the lower punctum: measuring the outer puntcal diametre, inner punctal diameter and punctal depth. Examination of the lower punctum was performed using Spectral Domain OCT machine; RTVue model-RT100 CAM system (Optovue Inc., Fremont, CA, USA) version 6.2, by attaching the cornea/anterior module lens (CAM). CAM lens has a wide-angle, high-magnification lens of 10 mm working distance. The axial resolution was 5 μm, and the lateral resolution was 8 μm. The scan beam has wavelength of 840 ± 10 nm. The two red external illumination (light emitting diode ) LED on headrest were approximated on each side of the lower punctum for proper illumination and imaging of the punctum. Gentle eversion of the medial part of the lower lid was performed to expose the lower lid punctum, so the vertical canaliculus was brought to be at an axial plain without undue stretching or pressure to the lower lid. Line scan was the used examination scan, containing 1020 A-scans/line, and is 8mm in length. Measurements of the external punctal diameter, internal punctal diameter, and punctal depth were performed on the B-scan image of the lower punctum (by selecting it from the Review window), using distance measurement tool. External punctal diameter was measured as a line connecting highest points on the medial and lateral punctal walls. Internal punctal diameter was measured as a horizontal line just above the narrowing. The distance between the line representing the external punctal diameter and the floor of the punctum was calculated and referred to the punctal depth Results: Data wil be collected and statistically analysed

Interventions

lower punctum examination by AS-OCT

Sponsors

Minia University
Lead SponsorOTHER

Study design

Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
40 Years to 60 Years
Healthy volunteers
Yes

Inclusion criteria

Patients with acquired punctal stenosis

Exclusion criteria

1. Punctal agenesis 2. Congenital punctal stenosis 3. Allergic occlusion 4. Lid malposition 5. Canalicular, nasolacrimal, sac and duct obstruction 6. Previous eyelid or lacrimal drainage surgery 7. Untreated conjunctivitis, blepharitis

Design outcomes

Primary

MeasureTime frameDescription
Lower punctum dimensions in cases with acquired punctual stenosis, compared with lower punctal dimensions in normal subjectsone monthExternal punctum diameter measured in µm, internal punctum diameter, measured in µ m, punctal depth measured in µ m

Contacts

Primary ContactHeba AttaAllah, MD
heba.ali@mu.edu.eg+201002554107

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026