Acute Chest Syndrome
Conditions
Keywords
Acute Chest Syndrome
Brief summary
This project is aiming to identify the diagnostic utility CEB (Cardiac Electrical Biomarker) in patients who are undergoing cardiac investigations.
Detailed description
This project is aiming to identify the diagnostic utility of an ECG derived measurement by a Medical device (Vectraplex by VectraCor ltd) in patients who are undergoing cardiac investigations. This technology is based on the principle of vector ECG and an analysing system that computes a composite score termed a Cardiac Electrical Biomarker (CEB TM). CEB has been validated in the detection of STEMI with high sensitivity and specificity in the detection ECG changes characteristic to STEMI. The CEB may be a more accurate way of identifying heart injury and causes of chest pain compared to standard tests, which could lead to faster diagnosis and treatment of these patients. The diagnostic utility of the CEBTM in the following: 1. Acute chest pain assessment in the A&E department. 2. Acute chest pain assessment in the Primary Care Surgery. 3. Performance of CEB during inducible ischaemia in patients with stable angina 4. Performance of CEB during acute ischaemia in patients undergoing percutaneous coronary intervention (PCI) 5. Performance of CEB in patients undergoing cardio-toxic treatment
Interventions
None listed
Sponsors
Joanne Turner
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Acute chest pain assessment in the Emergency department Inclusion criteria * Participant is willing and able to give informed consent for participation in the study * Male or Female, aged 18 years or above
Exclusion criteria
The participant may not enter the study if ANY of the following apply: * Unable or unwilling to give valid consent for participation in the study * Participant has been previously recruited to another module of the VECTRA ECG study * Participant has history of allergy to ECG electrode * Noisy ECG trace in spite of appropriate preparation and elimination of mains artefact and muscle tremor * ECG tracing with a wandering baseline * Sustained or non-sustained ventricular/atrial arrhythmia (Ventricular tachycardia, supraventricular tachycardia, atrial fibrillation, bigeminy and trigeminy) * QRS duration greater than 120 milliseconds * Q waves (except positional Q waves checked by deep inspiration) * Suspected Septicaemia, pulmonary embolism or aortic dissection * Recent history of trauma to thorax * Severe renal impairment with eGFR \<30 ml/min 2. Acute chest pain assessment in the Primary Care Surgery Inclusion criteria * Participant is willing and able to give informed consent for participation in the study. * Male or Female, aged 18 years or above. * Participants who have experienced chest pain more than 6 hours but less than 2 weeks of presentation to the surgery
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Diagnostic accuracy of CEB in detecting myocardial injury | Day 1 | Metrics: sensitivity, specificity, PPV, NPV |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Correlation between CEB and cardiovascular mortality | 30 days and 12 months | Cardiovascular death |
| Correlation between CEB and non-fatal myocardial infarction | 30 days and 12 months | Non-fatal myocardial infarction |
| Correlation between CEB and readmission with progressive angina | 30 days and 12 months | Readmission with angina after index admission |
| Relationship between CEB and need for revascularisation | 30 days and 12 months | Revascularisation (surgery or Percutaneous Coronary Intervention) from index admission |
Countries
United Kingdom
Contacts
Primary ContactAntoanela Colda
Backup ContactJoanne Turner
Outcome results
None listed