Multiple Sclerosis, Relapsing-Remitting
Conditions
Keywords
task-oriented training, exercise training, mobility, balance, fatigue, quality of life
Brief summary
Multiple Sclerosis (MS) is inflammatory, demyelinating and autoimmune disease of the central nervous system. It is usually seen with relapses and genetic and environmental factors play a role in the etiology. Neurological symptoms seen in MS restrict the patient's daily activity and social role participation. Mobility problems and fatigue are the most important reasons of role limitations and decreased quality of life. The importance of exercise training in disease management has been emphasized in recent years. However, few studies have investigated the effects of task-oriented trainings on symptoms of the disease. The aim of this sudy is to investigate the effects of task-oriented training additional to combined exercise training on functional capacity, mobility, balance, fatigue and quality of life in patients with MS.
Interventions
Aerobic training with cycle ergometer %60-80 of maximal Heart Rate, submaximal level, strengthening of the major muscles of upper and lower extremities
Functional reaching, walking on different obstacles and floor,sitting and standing on different levels and surface,walking around obstacle, climbing stairs with different height and surface
Sponsors
Bezmialem Vakif University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Multiple Sclerosis diagnosis * Expanded Disability Status Scale \> 5,5 * No cognitive problems * No relapses in the last 3 months * No other neurological or chronic disease
Exclusion criteria
* Relapse during the intervention * Exercise intolerance
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Functional capacity | 6 weeks | Change from baseline functional capacity with six minute walking test |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| limitation of gait | 6 weeks | Change from baseline functional mobility with MS walking scale-12 |
| dynamic balance and fall risk | 6 weeks | Change from baseline functional mobility with timed up and go test |
| sitatic balance | 6 weeks | Change from baseline balance with functional reach test |
| dynamic gait skills | 6 weeks | Change from baseline functional mobility with dynamic gait index |
| severity of fatigue | 6 weeks | Change from baseline fatigue with fatigue severity scale |
| impact of fatigue | 6 weeks | Change from baseline fatigue with fatigue impact scale |
| Quality of life | 6 weeks | Change from baseline quality of life with MS quality of life instrument-54 |
| dynamic balance | 6 weeks | Change from baseline balance with berg balance scale |
Contacts
Primary ContactKamer Unal-Eren, PT, PhD
Outcome results
None listed