Sepsis
Conditions
Brief summary
Breath samples will be collected from patients suspected of sepsis/severe sepsis or septic shock according to hospital sepsis screening criteria in the Emergency Department.
Detailed description
Breath samples will be collected from patients suspected of sepsis that meet the criteria in the hospital's Sepsis Patient Management Protocol for blood lactate point of care testing. The breath samples will be collected from the patient by the Respiratory Therapist (RT) at the time of blood sample collection for the blood lactate test. The breath samples will be analyzed via gas chromatography-surface acoustic wave spectroscopy for detection of a pattern of volatile organic compounds (VOCs). Multivariate analysis will be performed on breath sample data to determine feasibility of associating a unique VOC pattern with septic/severe septic/septic shock patients.
Interventions
DEVICEBreath sample collection
Subject exhales into breath collection container.
Sponsors
Landon Pediatric Foundation
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* admitted to Emergency Department * suspected of sepsis according to hospital screening criteria; point of care blood lactate test performed * age 18 or older
Exclusion criteria
* member of Vulnerable Patient Population * unable to complete Patient Informed Consent process/document
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Volatile Organic Compound (VOC) Pattern | five minutes | Detection of a unique pattern of Volatile Organic Compounds (VOCs) in the breath samples of patients confirmed as having sepsis/severe sepsis/septic shock differentiated from subjects confirmed as not septic. |
Countries
United States
Outcome results
None listed