Type 1 Diabetes Patients
Conditions
Brief summary
The improvement of imaging techniques in ophthalmology has made it possible to carry out a precise non-invasive study of the retinal microvascular network and to detect early abnormalities in retinal disorders. The presence of such early retinal abnormalities remains poorly known during type 1 diabetes and may be detected with OCT-angiography. Furthermore, the association with glycemic variability, likely to have deleterious effects on microvessels, has never been studied.
Interventions
PROCEDURERetinal imaging assessment
* OCT-angiography * Automated measurement program: size of the avascular zone and perifoveolar vascular density of the superficial capillary plexus * Eye fundus photography: macular image * Measurement of the fractal dimension of the retinal foveolar retina from photographs of the fundus
PROCEDUREblood glucose holter
for 40 subjects, implantation of a blood glucose holter monitor for 7 days
Sponsors
Centre Hospitalier Universitaire Dijon
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
For the patient group * Patient who has given consent * Type 1 diabetic patient, no retinopathy For the healthy control group * Patient who has given consent * Non-diabetic patient For dyslipidemic control group: * Person who has given consent * Person with familial dyslipidemia
Exclusion criteria
For the patient group * Presence of diabetic retinopathy * Protected patient: * Minor patient * Pregnant, parturient or breastfeeding woman * Patient under legal protection (guardianship, curatorship, court decision) * Patient unable to express consent Person not affiliated to a health insurance scheme For the healthy control group * Ophthalmological history (vascular and degenerative macular conditions) * Protected patient: * Minor patient * Pregnant, parturient or breastfeeding woman * Patient under legal protection (guardianship, curatorship, court decision) * Patient unable to express consent Person not affiliated to a social security scheme For dyslipidemic control group: * Ophthalmological history (vascular and degenerative macular conditions) * Protected patient: * Minor patient * Pregnant, parturient or breastfeeding woman * Patient under legal protection (guardianship, curatorship, court decision) * Patient unable to express consent Person not affiliated to a social security scheme
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| surface of the central retinal avascular zone | inclusion | measurement of superficial capillary plexus |
Countries
France
Outcome results
None listed