Registry for Evaluating Outcome of Acute Ischemic Stroke Patients Treated With Mechanical Thrombectomy.

Conditions

Ischemic Stroke

Keywords

Thrombectomy, Eligibility, Large vessel occlusion

Brief summary

The Bernese-European RegistrY for ischemic stroke patients treated Outside current guidelines with Neurothrombectomy Devices using the SOLITAIRE™ FR With the Intention For Thrombectomy (BEYOND-SWIFT) is a retrospective, multi-center, non-randomized observational study aims to investigate the safety and efficacy of a Medtronic market-released neurothrombectomy device (applied as initial devices used for intervention) in acute ischemic stroke patients who do not fulfill treatment eligibility according to current guidelines. Patients will be treated or were treated at the discretion of the investigator, independent of participation in this registry. Primary Analysis is the Impact of successful reperfusion on functional outcome at day 90 in patients presenting with large infarct cores (ASPECTS\<6) or minor symptoms (NIHSS\<8).

Adnan Mujanović, Christoph C. Kurmann, Tomas Dobrocky, Marta Olivé‐Gadea, Christian Maegerlein et al. (20 authors)

Frontiers in Neurology2022-08-0314 citations

10.3389/fneur.2022.945338

Effect of Pre- and In-Hospital Delay on Reperfusion in Acute Ischemic Stroke Mechanical Thrombectomy

Johannes Kaesmacher, Basel Maamari, Thomas R. Meinel, Eike I. Piechowiak, Pascal J. Mosimann et al. (23 authors)

Stroke2020-09-1632 citations

10.1161/strokeaha.120.030208

Association of initial imaging modality and futile recanalization after thrombectomy.

Meinel TR, Kaesmacher J, Mosimann PJ, Seiffge D, Jung S, Mordasini P, Arnold M, Goeldlin M, Hajdu SD, Olivé-Gadea M, Maegerlein C, Costalat V, Pierot L, Schaafsma JD, Fischer U, Gralla J.

2020-08-2652 citations

10.1212/wnl.0000000000010614

Endovascular Stroke Treatment and Risk of Intracranial Hemorrhage in Anticoagulated Patients

Thomas R. Meinel, Joachim U. Kniepert, David Seiffge, Jan Gralla, Simon Jung et al. (28 authors)

Stroke2020-01-2947 citations

10.1161/strokeaha.119.026606

Mechanical thrombectomy for basilar artery occlusion: efficacy, outcomes, and futile recanalization in comparison with the anterior circulation

Thomas R. Meinel, Johannes Kaesmacher, Panagiotis Chaloulos-Iakovidis, Leonidas D Panos, Pasquale Mordasini et al. (20 authors)

Journal of NeuroInterventional Surgery2019-06-25133 citations

10.1136/neurintsurg-2018-014516

Mechanical Thrombectomy in Ischemic Stroke Patients With Alberta Stroke Program Early Computed Tomography Score 0–5

Johannes Kaesmacher, Panagiotis Chaloulos-Iakovidis, Leonidas D Panos, Pasquale Mordasini, Patrik Michel et al. (18 authors)

Stroke2019-03-04130 citations

10.1161/strokeaha.118.023465

Clinical effect of successful reperfusion in patients presenting with NIHSS < 8: data from the BEYOND-SWIFT registry.

Kaesmacher J, Chaloulos-Iakovidis P, Panos L, Mordasini P, Heldner MR, Kurmann CC, Michel P, Hajdu SD, Ribo M, Requena M, Maegerlein C, Friedrich B, Costalat V, Benali A, Pierot L, Gawlitza M, Schaafsma J, Pereira VM, Gralla J, Fischer U.

2019-01-0814 citations

10.1007/s00415-018-09172-1

Outcome, efficacy and safety of endovascular thrombectomy in ischaemic stroke according to time to reperfusion: data from a multicentre registry

Thomas R. Meinel, Johannes Kaesmacher, Pasquale Mordasini, Pascal J. Mosimann, Simon Jung et al. (21 authors)

Therapeutic Advances in Neurological Disorders2019-01-0116 citations

10.1177/1756286419835708

Interventions

OTHERSuccessful reperfusion

Defined as modified Thrombolysis in Cerebral Infarction 2b/3

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Healthy volunteers

No

Inclusion criteria

* Patients or patient's legally authorized representative have given informed consent according to Good Clinical Practices (GCP) and/or IRB and/or local or institutional policies. * The patient presents with an intracranial large vessel occlusion and therewith-related neurological symptoms and has been or will be treated with a Medtronic marketed-release neurothrombectomy device (applied as first device to attempt retrieving the thrombus).

Exclusion criteria

* Current participation in another clinical trial

Design outcomes

Primary

Measure	Time frame	Description
3 month functional independence	0-90 days	Number of patients with modified Rankin Scale \<=2
Favourable outcome	0-90 days	Number of patients with modified Rankin Scale \<=3
Excellent outcome	0-90 days	Number of patients with modified Rankin Scale \<=1

Secondary

Measure	Time frame	Description
Successful reperfusion	Day 0	Number of patients with modified Thrombolysis in Cerebral Infarction 2b / 3
Mortality	Day 0-90	Number of patients with modified Rankin Scale 6
Symptomatic intracranial hemorrhage	Day 0-1	Number of patients with symptomatic intracranial hemorrhage according to ECASSII definition
Time to reperfusion	Day 0	Groin puncture to TICI2b/3

Countries

Switzerland

Outcome results

None listed