Minimally Conscious State, Vegetative State
Conditions
Keywords
disorders of consciousness, vegetative state, minimally conscious state, consciousness, pain assessment, nociception test
Brief summary
The aim of this study was to translate the NCS from English into Chinese and determine the validity of this Chinese version.
Detailed description
The assessment and early diagnosis of pain is of great importance for pain management and treatment in patients with disorders of consciousness. The Nociception Coma Scale (- Revised) is only applicable to assess pain of DOC patients in international clinical setting. The aim of this study was to translate the NCS from English into Chinese and determine the validity of this Chinese version. To test internal reliability and inter-rater reliability, both rater A and rater B assess the perception of pain on day 1; and to obtain test-retest reliability, rater A assessed all patients repeatedly on day 2. 'Faces, Legs, Activity, Cry, Consolability' (FLACC) was used to analysis concurrent validity by rater A.
Interventions
DIAGNOSTIC_TESTNociception Coma Scale (NCS)
Patients have been assessed with both the Nociception Coma Scale (NCS) and the FLACC.
Sponsors
Hangzhou Normal University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
DOUBLE (Subject, Investigator)
Intervention model description
The order of the administration was randomly selected. All patients' total scores assessed by rater A were recorded to test the internal consistency of NCS-R (A1). Meanwhile, to assess the concurrent validity, the scores of the FLACC were recorded together with NCS-R by rater A on day 1. In order to analyze the test-retest reliability, rater A complete the second evaluation of NCS-R on day 2 (A2)
Eligibility
Sex/Gender
ALL
Age
19 Years to 53 Years
Healthy volunteers
No
Inclusion criteria
* age ≥ 18 years old; * no administration of neuromuscular blockers or sedation within the 24 hours of enrolment; * the presence of periods of eye opening (indicating wakefulness and rest cycles); * a diagnosis of VS or MCS, based on more than 4 times behavioral assessment performed using the Coma Recovery Scale-Revised within 2 weeks.
Exclusion criteria
* Coma; * documented history of prior brain injury; * psychiatric or neurologic illness; * neuromuscular blocking agents or sedative drugs administered within the prior 24 hours; * no documented history of a prior coma, critical illness or unstable medical condition; * upper limb contusions, fractures (based on the imaging examination) or flaccid paralysis (by using noxious stimuli to upper limbs, motor sub-scale scores \<1).
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The level of perception of pain in DOC patients | Within 2 days | This original NCS consists of four subscales to assess motor, verbal, visual and facial behavioral responses and each subscale score ranges from 0 to 3 |
Countries
China
Outcome results
None listed