Gastric Cancer, Neoadjuvant Chemoradiotherapy, Neoadjuvant Chemotherapy, Nutrition Aspect of Cancer, Systemic Inflammatory Response Syndrome (SIRS)
Conditions
Brief summary
Based on multiple studies, the immune (systemic inflammation) and nutrition index were correlated with short- and long-term prognosis for gastric cancer. With the increasing application of preoperative treatments (chemotherapy and chemoradiotherapy), the issues concerning how are the immuno-nutrition index be altered under the effects of perioperative treatments and what are the clinical values of these index should be clarified.
Detailed description
The immune (systemic inflammation) index includes: NLR (Neutrophil-to-Lymphocyte Ratio); PLR (Platelet-to-Lymphocyte Ratio); SII (Systemic Immune-Inflammation Index); GPS (Glasgow Prognostic Score); mGPS (modified Glasgow Prognostic Score); PI (Prognostic Index); The nutrition index includes: NRS2002; PNI (Prognostic Nutrition Index);
Interventions
None listed
Sponsors
Peking University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* Histologically confirmed adenocarcinoma * Received neoadjuvant (preoperative) chemotherapy or chemoradiotherapy * Diagnosed clinical advanced gastric cancer or esophagogastric cancer
Exclusion criteria
* Lack of immuno-nutrition data
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Pathological response | One month after surgery | Pathological response |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| 3-years overall survival | Three years after surgery | 3-years overall survival |
| 3-years disease-free survival | Three years after surgery | 3-years disease-free survival |
| Postoperative morbidity | One month after surgery | Postoperative morbidity |
| yp TNM Stage | One month after surgery | yp TNM Stage |
Countries
China
Contacts
Primary ContactShuangxi Li, M.D., Ph.D.
Outcome results
None listed