Neurological Complication of Procedure (Disorder)
Conditions
Brief summary
In this single center prospective cohort study a total of 100 patients scheduled for elective off-pump CABG will be recruited. They will be allocated to one study and one control group according to the presence or absence of postoperative type 2 neurological complications. The two groups will be compared in terms of serum concentrations of glial fibrillary acidic protein (GFAP), neuroserpin (NSP), phosphorylated axonal neurofilament subunit H (pNfH) and visinin-like protein 1 (VILIP-1) at the time of skin incision and closure as well as 24 hours and 7 days following surgery. Diagnostic performance of these markers for predicting type 2 neurological complications of off-pump CABG will be assessed.
Interventions
OTHERexposure to type 2 neurological complications
exposure to postoperative cognitive dysfunction (POCD) or postoperative delirium (POD), or both concurrently.
Sponsors
Collegium Medicum w Bydgoszczy
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Inclusion criteria
* patients scheduled for elective off-pump Coronary Artery Bypass Grafting (CABG)
Exclusion criteria
* neurological or psychiatric disorders * alcohol or drug abuse * preoperative left ventricular ejection fraction of less than 30% * extracranial carotid artery stenosis of more than 70% * scoring below age- and education-adjusted cut-off values in Mini-Mental State Examination (MMSE) * scoring over seven points on the subscales of the Hospital Anxiety and Depression Scale (HADS)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Assessment of serum GFAP concentration (ng/ml) changes. | GFAP concentrations will be measured preoperatively (at the time of initial skin incision), at the completion of surgery (at the time of skin closure) as well as 24 hours and 7 days following off-pump Coronary Artery Bypass Grafting (CABG). | Comparison of patients with and without type 2 neurological complications in respect to changes from baseline concentration of glial fibrillary acidic protein (GFAP). |
| Assessment of serum NSP concentration (ng/ml) changes. | NSP concentrations will be measured preoperatively (at the time of initial skin incision), at the completion of surgery (at the time of skin closure) as well as 24 hours and 7 days following off-pump Coronary Artery Bypass Grafting (CABG). | Comparison of patients with and without type 2 neurological complications in respect to changes from baseline concentration of neuroserpin (NSP). |
| Assessment of serum pNfH concentration (ng/ml) changes. | pNfH concentrations will be measured preoperatively (at the time of initial skin incision), at the completion of surgery (at the time of skin closure) as well as 24 hours and 7 days following off-pump Coronary Artery Bypass Grafting (CABG). | Comparison of patients with and without type 2 neurological complications in respect to changes from baseline concentration of neuroserpin phosphorylated axonal neurofilament subunit H (pNfH). |
| Assessment of serum VILIP-1 concentration (ng/ml) changes. | VILIP-1 concentrations will be measured preoperatively (at the time of initial skin incision), at the completion of surgery (at the time of skin closure) as well as 24 hours and 7 days following off-pump Coronary Artery Bypass Grafting (CABG). | Comparison of patients with and without type 2 neurological complications in respect to changes from baseline concentration of visinin-like protein 1 (VILIP-1). |
Countries
Poland
Outcome results
None listed