Bronchiolitis
Conditions
Keywords
High Flow Nasal Cannula
Brief summary
This is a pilot study comparing a weight-based high-flow nasal cannula (HFNC) protocol with the current standard HFNC protocol for children \<2yo admitted to South Shore Hospital with bronchiolitis. We currently use a flat limit of 8 liters of HFNC to support work of breathing and hypoxia in these patients. We will compare that to a weight-based protocol, which will provide 2L/kg/min of flow (flows generally between 6 and 20L/minute) to this patient population. The goal of this pilot study is to assess the feasibility of our study design. We will evaluate the functionality of a new weight-based flow protocol. We will also evaluate the functionality of a new bronchiolitis scoring tool, the Bronchiolitis Assessment Severity Score (BASS), and it's ability to guide care through the new protocol. We are also testing the feasibility of recruitment, randomization and retention. We are ultimately interested in whether a weight-based flow protocol reduces need for escalation to ICU-level care for children with moderate-severe bronchiolitis on HFNC.
Detailed description
This is a pilot study comparing a weight-based high-flow nasal cannula (HFNC) protocol with the current standard HFNC protocol for children \<2yo admitted to South Shore Hospital with bronchiolitis. We currently use a flat limit of 8 liters of HFNC to support work of breathing and hypoxia in these patients. We will compare that to a weight-based protocol, which will provide 2L/kg/min of flow (flows generally between 6 and 20L/minute) to this patient population. The goal of this pilot study is to assess the feasibility of our study design. We will evaluate the functionality of a new weight-based flow protocol. We will also evaluate the functionality of a new bronchiolitis scoring tool, the Bronchiolitis Assessment Severity Score (BASS), and it's ability to guide care through the new protocol. We are also testing the feasibility of recruitment, randomization and retention. We are ultimately interested in whether a weight-based flow protocol reduces need for escalation to ICU-level care for children with moderate-severe bronchiolitis on HFNC.
Interventions
OTHERWeight-Based Flow for High Flow Nasal Cannula (HFNC) (2L/kg/minute)
A weight-based flow for HFNC.
OTHERStandard Flow for HFNC (Maximum 8L/minute)
Maximum flow of 8L/minute.
Sponsors
South Shore Hospital
Boston Children's Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
No minimum to 2 Years
Healthy volunteers
No
Inclusion criteria
* admission to inpatient pediatrics * clinical diagnosis of bronchiolitis * BASS score of moderate or severe
Exclusion criteria
* non-english speakers * patients with urgent need for CPAP, BIPAP or intubation
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Treatment failure | During hospital admission | Need for escalation to NIV (CPAP or BIPAP) or intubation |
| Length of Stay | During hospital admission | Length of hospital stay (admission to discharge or transfer) |
Countries
United States
Outcome results
None listed