The Role of Music Stimulation in Disorders of Consciousness State: an fMRI Study

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03492294

Enrollment

Registered

2018-04-10

Start date

2008-12-31

Completion date

2018-04-30

Last updated

2018-04-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Minimally Conscious State, Vegetative State

Keywords

disorders of consciousness, music stimulation, functional magnetic resonance imaging

Brief summary

The aim of the present study was to evaluated the neural effect of music on the cerebral activation in unresponsive wakefulness syndrome (UWS) and minimally conscious state (MCS) by using functional magnetic resonance imaging (fMRI).

Detailed description

Background: Sensory stimulations were used widely to evaluate the preserved cerebral functions for these patients with disorders of consciousness. Among these, the most alerting or common stimuli are probably familiar voice and music. Objective: The aim of the present study was to evaluated the neural effect of music on the cerebral activation in unresponsive wakefulness syndrome (UWS) and minimally conscious state (MCS) by using functional magnetic resonance imaging (fMRI). Methods: Eleven severely brain-damaged patients (6 UWS and 5 MCS) were assessed by functional magnetic resonance imaging while they were exposed under the condition of their personal music. To examine the prognostic value of these patients, longitudinal behavioral assessments were repeatedly conducted by means of the CRS-R after fMRI acquisition.

Interventions

DIAGNOSTIC_TESTfunctional magnetic resonance imaging

Patients with disorders of consciousness were assessed by functional magnetic resonance imaging while they were exposed under the condition of music.

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

21 Years to 61 Years

Inclusion criteria

* age ≥ 18 years old; * no administration of neuromuscular blockers or sedation within the 24 hours of enrolment; * brain damage with eye opening (indicating wakefulness and rest cycles)

Exclusion criteria

* Coma; * neurodegenerative disease; * psychiatric or neurologic illness; * with intracranial metal or other body metal.

Design outcomes

Primary

Measure	Time frame	Description
Coma Recovery Scale-Revised	one to two years	examine the prognostic value of these patients, longitudinal behavioral assessments were repeatedly conducted by means of the CRS-R after fMRI acquisition

Countries

China

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026