Rehabilitative Nutrition for Muscle Recovery From ACL Reconstruction
Conditions
Keywords
rehabilitative nutrition, protein, beef, ACL reconstruction, protein synthesis, proteolysis, muscle mass, muscle strength
Brief summary
Musculoskeletal injury, particularly injuries requiring surgical repair, induce significant muscle atrophy, resulting in diminished physical function. The protein turnover-associated (diminished protein synthesis, elevated protein breakdown, negative net muscle protein balance) etiology of injury and surgical-induced atrophy are, in part, similar to those observed with muscle wasting induced by hyper-catabolic and inflammatory conditions and prolonged periods of skeletal muscle disuse (e.g., cachexia and joint immobilization). Combining dietary strategies to optimize the anabolic properties of beef as a high quality protein source that provides essential amino acids prior to surgery and throughout post-surgery rehabilitation may attenuate muscle atrophy and accelerate the restoration of muscle function. This project will examine the efficacy of habitual consumption of a beef-based higher protein meal pattern and post-physical rehabilitation beef protein supplementation throughout post-surgical rehabilitation intervention on skeletal muscle function in response to anterior cruciate ligament (ACL) repair in healthy, physically active adults. Stable isotope methodologies, proteomic analysis of muscle protein synthesis, and molecular assessments of skeletal muscle atrophy and remodeling will be assessed to evaluate the effects of increased protein intake, including consumption of a high quality beef-based protein supplement following patient physical therapy sessions on: 1. Skeletal muscle protein fractional synthetic rates during and in recovery from surgery; 2. Inflammatory, proteolytic, and anabolic intramuscular signaling during surgery and their association with skeletal muscle protein synthesis and muscle function; 3. Muscle size and functional recovery; 4. Duration to return to routine exercise, sport, or physical activity.
Interventions
OTHERDiet Intervention_AP-CPT
Adequate Protein\_Carbohydrate Post Therapy (AP-CPT) where protein intake will be 1 g/kg/d for the duration of the study .
OTHERDiet Intervention_PP-PPT
Optimal Protein\_Protein Post Therapy (OP-PPT) with protein intake set at 2.0 g/kg/day for the duration of the study
Sponsors
Orthopedic Associates of Hartford
United States Army Research Institute of Environmental Medicine
University of California, Berkeley
University of Connecticut
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
* 18 to 50 years of age * identified as appropriate for study recruitment by their respective orthopedic surgeon * undergoing their first anterior cruciate ligament (ACL) repair * undergo ACL reconstruction under general anesthesia * body mass indexes (BMIs) within normal to overweight ranges
Exclusion criteria
* reporting metabolic or cardiovascular abnormalities, food allergies, gastrointestinal disorders (i.e. lactose intolerance) * use of nutritional/herbal/sports supplements including anabolic steroids, and tobacco products will be excluded from the study * BMIs above 29.9
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Skeletal muscle protein fractional synthetic rates | Following 16 weeks of physical rehabilitation post surgery for subjects in both diet intervention groups. | Using stable isotope techniques skeletal muscle protein fractional synthetic rates will be determined |
Countries
United States
Outcome results
None listed