Induction of Labor
Conditions
Keywords
Induction of labor, Misoprostol, Failed induction
Brief summary
To compare two protocols of misoprostol use for cervical ripening: 3 doses (25 ug vaginal each) or up to six doses, every six hours, until an adequate cervical condititon was achieved (BIshop score \> 6). In the first group, after 3 doses, the patient was sent to the delivery room for induction with oxytocin and in case of failure, a cesarean section was indicated for this reason. In the second group, up to six doses were used in a similar fashion. Rates of success were evaluated, as well as maternal and fetal complications.
Interventions
PROCEDURE6 misoprostol
Up to 6 doses of 25ug of misoprostol applied every 6 hours. End point is cervical Bishop score \> 6.
PROCEDURE3 misoprostol
Up to 3 doses of 25ug of misoprostol applied every 6 hours. End point is cervical Bishop score \> 6.
Sponsors
Sistema Nacional de Investigadores de Panamá
Saint Thomas Hospital, Panama
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Healthy volunteers
No
Inclusion criteria
* Pregnant women between 34 and 42 weeks of gestation. * Obstetric indication for termination of pregnancy. * No fetal evidence of fetal distress
Exclusion criteria
* Any contraindication for the use of misoprostol. * Oligohydramnios.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Vaginal birth | 48 hours | Number of patients that had a vaginal birth |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Maternal complications | 48 hours | Number of patients that developed a maternal complication due to the use of misoprostol (abruptio placenta, postpartum bleeding, uterine atony). |
| Fetal complications | 48 hours | Number of patients that developed a fetal complication due to the use of misoprostol (stillbirth, fetal distress). |
Countries
Panama
Outcome results
None listed