Lupus Erythematosus, Systemic, Coronary Artery Disease, Myocardial Disease
Conditions
Brief summary
In systemic lupus erythematosus (SLE), cardiac manifestations, e.g. coronary artery disease (CAD) and myocarditis are leading causes of morbidity and mortality. The prevalence of subclinical heart disease in SLE is unknown. We studied whether a comprehensive cardiovascular magnetic resonance (CMR) protocol may be useful for early diagnosis of heart disease in SLE patients without known CAD
Interventions
DIAGNOSTIC_TESTCardiovascular magnetic resonance
CMR including cine, late gadolinium enhancement (LGE) and stress perfusion sequences
Sponsors
University Hospital, Basel, Switzerland
Study design
Observational model
OTHER
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* diagnosis of SLE, as defined by the American College of Rheumatology Classification Criteria for Systemic Lupus Erythematosus
Exclusion criteria
* age under 18 years * known coronary artery disease * impaired renal function with an estimated glomerular filtration rate less than 30 ml/min, estimated by the Modification of Diet in Renal Disease Study Group (MDRD) formula (45) * devices as pacemakers, implantable cardioverter-defibrillators, insulin pumps and others * metallic foreign bodies in the eyes, ferromagnetic implants labeled MR unsafe * allergy against CMR contrast media or adenosine * presence of chronic atrial fibrillation, 2nd or 3rd degree Atrioventricular (AV)-block, trifascicular block, asthma and severe chronic obstructive pulmonary disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Prevalence of cardiovascular pathologies identified by CMR in patients with SLE | at baseline |
Countries
Switzerland
Outcome results
None listed