Migraine
Conditions
Brief summary
The purpose of this study is to identify a core fMRI feature that determines migrainous brain and plastic fMRI features that changes with longitudinal courses of migraine.
Detailed description
Migraine is associated with functional alterations in specific brain networks. The investigators aimed to identify network abnormalities which remain unchanged throughout the longitudinal course of migraine. The investigators also aimed to identify networks which change in association with changes in migraine frequency and associated psychiatric conditions. The investigators expect these can serve as neuroimaging biomarkers for diagnosis of migraine brain and monitoring of disease severity.
Interventions
DIAGNOSTIC_TESTresting-state functional MRI
1. To ensure inter-ictal fMRI, confirm that the subject has no migraine for at least 48 hours before the procedure. 2. Record the time difference between the date on the day of fMRI and the date of the last headache attack and record whether the headache on the day of fMRI is absent or not. 3. On the third day after MRI, examine whether the subject has headache or not.
Sponsors
National Research Foundation of Korea
Sungkyunkwan University
Samsung Medical Center
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
Migrainuers : 1. age 18-50 years 2. migraine with or without aura as defined by the third edition of the International Classification of Headache Disorders (ICHD-3 beta) 3. if female, before the onset of menopausal Controls: 1. age 18-50 years 2. no headache disorder other than Infrequent episodic tension-type headache as defined by the ICHD-3 beta
Exclusion criteria
1. contraindicated to MRI 2. pregnancy 3. require sedation treatment because of claustrophobia when performing MRI 4. predicted to be unable to write the headache diary due to cognitive decline 5. refuse study procedure
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Core fMRI features for migraine brain | 1-year follow-up (2nd year) | Among significant networks identified by ICA, we will identify altered networks which remain unchanged in follow-up resting-state fMRI in 1 year. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Candidate fMRI features for migraine | Baseline (1st year) | Using baseline resting-state fMRI, altered brain networks associated with migraine will be identified by independent component analysis (ICA) between patients and controls. |
| Dynamic fMRI features for disease severity | 1-year follow-up (2nd year) | Among significant networks identified by ICA, we will identify altered networks which change in association with changes in headache frequency in follow-up resting-state fMRI in 1 year. |
Countries
South Korea
Outcome results
None listed