Alzheimer Disease, Intestinal Microbiota
Conditions
Brief summary
The objective of the study is to highlight a modification of the composition of the intestinal microbiota associated with the diagnosis of Alzheimer's disease and its most unfavorable form, Rapid Cognitive Decline (DCR). This identification could lead to diagnostic strategies based on the analysis of the intestinal microbiome, and preventive and curative treatments, based on the modulation of intestinal microbiota
Interventions
PROCEDUREFecal sample collection
Fecal sample collection
Sponsors
Nantes University Hospital
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
NONE
Intervention model description
The study will compare three groups of 100 patients, corresponding to 200 patients with Alzheimer disease (whom 100 patients in the rapid cognitive decline group and 100 patients without rapid cognitive decline) and 100 patients in the control group.
Eligibility
Sex/Gender
ALL
Age
70 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
For Alzheimer groups without DCR and Alzheimer with DCR: * patients between 70 and 90 years old * with mild to moderate Alzheimer's disease (MMSE\> 15/30), * followed in the CMRR of the University Hospital of Nantes or Angers * having given their informed consent For the control group (non-Alzheimer's) * more patients between 70 and 90 years * consultant for a subjective memory complaint isolated at the CMRR of Nantes or Angers University Hospital, * having given their informed consent
Exclusion criteria
* Major patients under tutorship, curatorship or safeguard of justice * Cognitive disorders possibly related to a metabolic or psychiatric cause * History of prescription of antibiotic treatment in the last month * History of acute gastrointestinal illness in the last month * History of hospitalization for an acute medical pathology or for a surgical procedure in the last month
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| analysis of the taxonomic and functional composition of the microbiome | 1 year | (shotgun sequencing), in patients with DCR (loss of at least 3 points in the MMSE at 1 year. |
Secondary
| Measure | Time frame |
|---|---|
| create a prognostic score of DCR based on clinical data, including the responses to the MMSE, BREF and MNA questionnaires, and taking into account the microbiota analysis | 1 year |
| to determine if there is a specific modification of the composition of the intestinal microbiota of patients with Alzheimer's disease, compared to control group. | Day 0 |
Countries
France
Outcome results
None listed