Medical Abortion With Single Daily Dose of Misoprostol

Medical Abortion With Multiple vs Single Daily Dose of Misoprostol in First Trimester Miscarriage: A Randomized Clinical Trial.

Status

Completed

Phases

Phase 2Phase 3

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03487354

Enrollment

200

Registered

2018-04-04

Start date

2018-04-01

Completion date

2019-01-10

Last updated

2019-01-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Miscarriage

Brief summary

Medical abortion using multiple vs single daily dose of misoprostol in first trimester miscarriage.

Interventions

DRUGMisoprostol

Misoprostol

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 40 Years

Healthy volunteers

Inclusion criteria

* Maternal age more than 18 years old (age of legal consent). * Gestational age less than 13 weeks. * Hemoglobin \>10 g/dL. * BMI between 25 kg/m2 and 35 kg/m2. * Missed abortion. * Living fetus with multiple congenital malformations incompatible with life.

Exclusion criteria

* Maternal age less than 18 years old. * Gestational age more than 12 weeks. * Hemoglobin \<10 g/dL. * Anencephaly. * Fibroid uterus. * BMI less than 25kg/m2 and more than 35kg/m2. * Coagulopathy. * History or evidence of adrenal pathology. * Previous attempts for induction of abortion in the current pregnancy. * Allergy to misoprostol or letrozole. * Medical disorder that contraindicate induction of abortion (e.g. heart failure).

Design outcomes

Primary

Measure	Time frame	Description
Complete miscarriage	one week	Assessed by trans-vaginal ultrasound where endometrial thickness less than 15 mm is considered complete miscarriage

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026