Stroke, Aphasia, Cognitive Impairment
Conditions
Keywords
transcranial direct current stimulation, dual stimulation
Brief summary
The aim of this study is to investigate the effect of dual site-dual channel non-invasive brain stimulation for recovery of language and cognitive function in post stroke patients. Simultaneous dual site-dual channel stimulation was applied by using two sets of transcranial direct current stimulation devices. All subjects will go through four conditions of transcranial direct current stimulation with for 30 minutes. Four conditions are 1) Dual stimulation: i) anodal stimulation on ipsilesional inferior frontal cortex, ii) anodal stimulation on ipsilesional dorsolateral prefrontal cortex. 2) Single stimulation 1: anodal stimulation on ipsilesional inferior frontal cortex and cathodal stimulation on contralesional inferior frontal cortex; 3) Single stimulation 2: anodal stimulation on ipsilesional inferior frontal cortex and cathodal stimulation on contralesional supraorbital area.
Interventions
DEVICEIFG stimulation
stimulating inferior frontal cortex with transcranial direct current stimulation for 30 minutes
DEVICEDLPFC stimulation
stimulating dorsolateral prefrontal cortex with transcranial direct current stimulation for 30 minutes
BEHAVIORALaphasia therapy
aphasia therapy for 30 minutes during transcranial direct current stimulation
Sponsors
Samsung Medical Center
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
19 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* left hemisphere involved stroke patients * patients diagnoses as post stroke aphasia
Exclusion criteria
* history of psychiatric disease * patients with metal implants * history of epilepsy * pregnancy * skin defect at the site of electrode attachment
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Changes in Korean Boston naming test | Baseline and after intervention (approximately 2 weeks) | measures naming ability thorough picture naming test |
| Changes in Korean Western Aphasia Battery | Baseline and after intervention (approximately 2 weeks) | assessment of language function and provide aphasia quotients |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Korean Color Word Stroop test | Baseline and after intervention (approximately 2 weeks) | measures selective attention and executive function |
| Controlled Oral Word Association Test | Baseline and after intervention (approximately 2 weeks) | measure verbal fluency |
| Digit span test | Baseline and after intervention (approximately 2 weeks) | measures memory span |
| Changes in brain activation of resting-state and task functional MRI | Baseline and after intervention (approximately 2 weeks) | Neuroplasticity measure |
| Changes of Cortical activation | Baseline and after intervention (approximately 2 weeks) | Cortical activation is measured by functional Near-Infrared-Spectroscopy (fNIRS) (NIRScout, NIRx, Germany) |
| Korea Montreal Cognitive Assessment | Baseline and after intervention (approximately 2 weeks) | measure cognitive function |
Countries
South Korea
Outcome results
None listed